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The dynamic synapse

机译:动态突触

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The constant dynamic movement of synapses and their components has emerged in the last decades as a key feature of synaptic transmission and its plasticity. Intramolecular protein movements drive conformation changes important to transduce transmitter binding into signaling. Constant cytoskeletal rearrangements power synapse shape movements. Vesicular trafficking at the pre- and postsynapse underlies transmitter release and receptor traffic between the cell surface and intracellular compartments, respectively. Receptor movement in the plane of the plasma membrane by thermally powered Brownian diffusion movement and reversible trapping by receptor-scaffold interactions has emerged as the main mechanism to dynamically organize the synaptic membrane in nanoscale domains. We will discuss here the different conceptual and methodological advances that have led to a rethinking of the synapse as an organelle whose function is tightly linked to its dynamic organization.
机译:在过去的几十年中,突触及其组成部分的不断动态运动已成为突触传递及其可塑性的关键特征。分子内蛋白质运动驱动构象变化,这对于将递质结合转化为信号十分重要。恒定的细胞骨架重排为突触形状运动提供动力。突触前和突触后的水泡运输分别是细胞表面和细胞内区室之间的递质释放和受体运输的基础。通过热动力布朗扩散运动和通过受体-支架相互作用引起的可逆捕获,质膜平面中的受体运动已经成为在纳米级域动态组织突触膜的主要机制。我们将在这里讨论不同的概念和方法上的进展,这些进展已导致重新思考突触作为一种细胞器,其功能与其动态组织紧密相关。

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