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首页> 外文期刊>Neuron >Multiple mechanisms switch an electrically coupled, synaptically inhibited neuron between competing rhythmic oscillators.
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Multiple mechanisms switch an electrically coupled, synaptically inhibited neuron between competing rhythmic oscillators.

机译：多种机制在竞争性节奏振荡器之间切换电耦合，突触抑制的神经元。

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摘要

Rhythmic oscillations are common features of nervous systems. One of the fundamental questions posed by these rhythms is how individual neurons or groups of neurons are recruited into different network oscillations. We modeled competing fast and slow oscillators connected to a hub neuron with electrical and inhibitory synapses. We explore the patterns of coordination shown in the network as a function of the electrical coupling and inhibitory synapse strengths with the help of a novel visualization method that we call the "parameterscape." The hub neuron can be switched between the fast and slow oscillators by multiple network mechanisms, indicating that a given change in network state can be achieved by degenerate cellular mechanisms. These results have importance for interpreting experiments employing optogenetic, genetic, and pharmacological manipulations to understand circuit dynamics.
机译：节律性振荡是神经系统的常见特征。这些节律引起的基本问题之一是如何将单个神经元或神经元组募集到不同的网络振荡中。我们对连接到具有电和抑制突触的中枢神经元的快速和慢速振荡器进行了建模。我们借助一种新颖的可视化方法（称为“ parameterscape”），探索了网络中作为电耦合和抑制突触强度函数的协调模式。可以通过多种网络机制在快速和慢速振荡器之间切换集线器神经元，这表明网络状态的给定变化可以通过退化的细胞机制来实现。这些结果对于解释采用光遗传学，遗传学和药理学操作来理解电路动力学的实验具有重要意义。

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