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Structured Synaptic Connectivity between Hippocampal Regions

机译:海马区之间的结构化突触连接。

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The organization of synaptic connectivity within a neuronal circuit is a prime determinant of circuit function. We performed a comprehensive fine-scale circuit mapping of hippocampal regions (CA3-CA1) using the newly developed synapse labeling method, mGRASP. This mapping revealed spatially nonuniform and clustered synaptic connectivity patterns. Furthermore, synaptic clustering was enhanced between groups of neurons that shared a similar developmental/migration time window, suggesting a mechanism for establishing the spatial structure of synaptic connectivity. Such connectivity patterns are thought to effectively engage active dendritic processing and storage mechanisms, thereby potentially enhancing neuronal feature selectivity.
机译:神经回路内突触连接的组织是回路功能的主要决定因素。我们使用新开发的突触标记方法mGRASP对海马区(CA3-CA1)进行了全面的精细电路绘图。该映射揭示了空间上不均匀和聚集的突触连接模式。此外,在共享相似的发育/迁移时间窗口的神经元组之间,突触聚类得到了增强,这表明建立突触连通性空间结构的机制。这种连接模式被认为可以有效地参与主动的树突处理和存储机制,从而潜在地增强神经元特征的选择性。

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