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首页> 外文期刊>Neuron >Regional diversity and developmental dynamics of the AMPA-receptor proteome in the mammalian brain
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Regional diversity and developmental dynamics of the AMPA-receptor proteome in the mammalian brain

机译：哺乳动物大脑中AMPA受体蛋白质组的区域多样性和发育动力学

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Native AMPA receptors (AMPARs) in the mammalian brain are macromolecular complexes whose functional characteristics vary across the different brain regions and change during postnatal development or in response to neuronal activity. The structural and functional properties of the AMPARs are determined by their proteome, the ensemble of their protein building blocks. Here we use high-resolution quantitative mass spectrometry to analyze the entire pool of AMPARs affinity-isolated from distinct brain regions, selected sets of neurons, and whole brains at distinct stages of postnatal development. These analyses show that the AMPAR proteome is dynamic in both space and time: AMPARs exhibit profound region specificity in their architecture and the constituents building their core and periphery. Likewise, AMPARs exchange many of their building blocks during postnatal development. These results provide a unique resource and detailed contextual data sets for the analysis of native AMPAR complexes and their role in excitatory neurotransmission.
机译：哺乳动物大脑中的天然AMPA受体（AMPAR）是大分子复合物，其功能特征在不同的大脑区域之间变化，并在产后发育或响应神经元活动时发生变化。 AMPAR的结构和功能特性取决于其蛋白质组，即蛋白质构建模块的整体。在这里，我们使用高分辨率定量质谱分析从不同的大脑区域，选定的神经元组和出生后不同阶段的整个大脑亲和分离的AMPAR的整个池。这些分析表明，AMPAR蛋白质组在时间和空间上都是动态的：AMPAR在其体系结构和构成其核心和外围的成分方面表现出深远的区域特异性。同样，AMPAR在产后发育过程中交换了许多构件。这些结果为分析天然AMPAR复合物及其在兴奋性神经传递中的作用提供了独特的资源和详细的背景数据集。

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