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Odor Processing by Adult-Born Neurons

机译:成年神经元的气味处理

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The adult mammalian brain is continuously supplied with adult-born neurons in the olfactory bulb (OB) and hippocampus, where they are thought to be important for circuit coding and plasticity. However, direct evidence for the actual involvement of these neurons in neural processing is still lacking. We recorded the spiking activity of adult-born periglo-merular neurons in the mouse OB in vivo using two-photon-targeted patch recordings. We show that odor responsiveness reaches a peak during neuronal development and then recedes at maturity. Sensory enrichment during development enhances the selectivity of adult-born neurons after maturation, without affecting neighboring resident neurons. Thus, in the OB circuit, adult-born neurons functionally integrate into the circuit, where they acquire distinct response profiles in an experience-dependent manner. The constant flow of these sensitive neurons into the circuit provides it with a mechanism of long-term plasticity, wherein new neurons mature to process odor information based on past demands.
机译:成年哺乳动物的大脑在嗅球(OB)和海马体中不断供应成年出生的神经元,据认为它们对于电路编码和可塑性至关重要。但是,仍然缺少这些神经元实际参与神经加工的直接证据。我们使用靶向两个光子的贴片记录在小鼠OB体内记录了成年出生的肾小球周围神经元的突触活性。我们表明,在神经元发育过程中,气味响应能力达到峰值,然后在成熟时消退。发育过程中的感官富集增强了成熟后成人出生的神经元的选择性,而不会影响邻近的驻留神经元。因此,在OB回路中,成年出生的神经元在功能上整合到回路中,在那里它们以依赖于经验的方式获得不同的响应曲线。这些敏感神经元不断流入电路为电路提供了长期可塑性的机制,其中新的神经元会根据过去的需求成熟以处理气味信息。

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