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首页> 外文期刊>Neuron >Cux2-Positive Radial Glial Cells Generate Diverse Subtypes of Neocortical Projection Neurons and Macroglia
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Cux2-Positive Radial Glial Cells Generate Diverse Subtypes of Neocortical Projection Neurons and Macroglia

机译:Cux2阳性Rad神经胶质细胞产生新皮层投射神经元和巨胶质细胞的不同亚型。

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We recently published genetic lineage-tracing experiments using the Fezf2 and Cux2 loci. These experiments demonstrated that at both the clonal and population levels Fezf2(+) RGCs are multipotent and that at the population level Cux2(+) RGCs are multipotent. Here, we extend our work on the lineages of Fezf2(+) and Cux2(+) RGCs. Clonal analysis of E10.5 neocortical progenitors suggests that most, if not all, Cux2(+) and Fezf2(+) RGCs generate diverse projection neuron subtypes located throughout layers 2-6. These results support our previous conclusion that both Fezf2(+) and Cux2(+) RGCs are multipotent neocortical progenitors. This Matters Arising Response paper addresses the Gil-Sanz et al. (2015) Matters Arising paper, published concurrently in Neuron.
机译:我们最近发表了使用Fezf2和Cux2基因座的遗传谱系追踪实验。这些实验表明,在克隆水平和群体水平上,Fezf2(+)RGC都是多能的,而在群体水平上Cux2(+)RGC是多能的。在这里,我们将工作扩展到Fezf2(+)和Cux2(+)RGC的世系。 E10.5新皮质祖细胞的克隆分析表明,大多数(如果不是全部)Cux2(+)和Fezf2(+)RGC会产生遍及第2-6层的多种投影神经元亚型。这些结果支持我们先前的结论,即Fezf2(+)和Cux2(+)RGC都是多能性新皮质祖细胞。此问题引起的回应论文针对Gil-Sanz等。 (2015)Matters Arising论文,同时发表在Neuron上。

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