• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neurochemical research >Comparison of the immunoreactivity of Trx2/Prx3 redox system in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia.
【24h】

Comparison of the immunoreactivity of Trx2/Prx3 redox system in the hippocampal CA1 region between the young and adult gerbil induced by transient cerebral ischemia.

机译：短暂性脑缺血诱导的幼小和成年沙鼠海马CA1区Trx2 / Prx3氧化还原系统免疫反应的比较。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In the present study, we compared the immunoreactivities and levels of Trx/prx redox system, thioredoxin 2 (Trx2), thioredoxin reductase 2 (TrxR2) and peroxiredoxin 3 (Prx3), as well as neuronal death in the hippocampal CA1 region between the adult and young gerbil after 5 min of transient cerebral ischemia. At 4 days post-ischemia, pyramidal neurons (about 90%) in the adult stratum pyramidale of the CA1 region showed "delayed neuronal death (DND)"; however, at this time point, few pyramidal neurons showed DND in the young stratum pyramidale. At 7 days post-ischemia, about 56% of pyramidal neurons showed DND in the young stratum pyramidale. The immunoreactivities of all the antioxidants in the young sham-group were similar to those in the adult sham-group. At 4 days post-ischemia, the immunoreactivity of TrxR2, not Trx2 and Prx3 in the adult ischemia-group was dramatically decreased in CA1 pyramidal neurons. At this time point, the immunoreactivities of all the antioxidants in the young ischemia-group were apparently increased compared to the adult ischemia-group. From 7 days pots-ischemia, non-pyramidal cells showed the immunoreactivities of all the antioxidants in the ischemic CA1 region; however, in the young ischemia-groups, the immunoreactivities were much lower than those in the adult ischemia-groups. In brief, our results showed that the immunoreactivities of Trx2, TrxR2 and Prx3 were dramatically increased in CA1 pyramidal neurons of the young ischemia-groups at 4 days post-ischemia compared to those in the adult ischemia-groups induced by transient cerebral ischemia.
机译：在本研究中，我们比较了成年人之间海马CA1区Trx / prx氧化还原系统，硫氧还蛋白2（Trx2），硫氧还蛋白还原酶2（TrxR2）和过氧化物酶3（Prx3）的免疫反应性和水平以及神经元死亡短暂性脑缺血5分钟后和年轻沙鼠。缺血后第4天，CA1区成年锥体中的锥体神经元（约90％）显示为“神经元延迟死亡（DND）”。然而，在这个时候，很少有锥体神经元在年轻的锥体中显示出DND。缺血后7天，约56％的锥体神经元在年轻的锥体中显示DND。假假组中所有抗氧化剂的免疫反应性均与成年假组中的相似。缺血后第4天，在CA1锥体神经元中，成年缺血组的TrxR2而非Trx2和Prx3的免疫反应性显着降低。在这个时间点，与成人缺血组相比，年轻缺血组中所有抗氧化剂的免疫反应性明显增加。在盆缺血7天后，非锥体细胞在缺血CA1区表现出所有抗氧化剂的免疫反应性。然而，在年轻的缺血组中，其免疫反应性远低于成人的缺血组。简而言之，我们的结果表明，与短暂性脑缺血诱导的成人缺血组相比，缺血后4天的年轻缺血组的CA1锥体神经元中Trx2，TrxR2和Prx3的免疫反应性显着增加。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号