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首页> 外文期刊>Neuron >Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding (see comments)
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Dosage-sensitive, reciprocal genetic interactions between the Abl tyrosine kinase and the putative GEF trio reveal trio's role in axon pathfinding (see comments)

机译：Abl酪氨酸激酶与推定的GEF三重基因之间的剂量敏感，相互的遗传相互作用揭示了三重基因在轴突寻路中的作用（参见评论）

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摘要

The Abelson tyrosine kinase (Abl) is integrated into signal transduction networks regulating axon outgrowth. We have identified the Drosophila trio gene through a mutation that exacerbates the Abl mutant phenotype. Drosophila Trio is an ortholog of mammalian Trio, a protein that contains multiple spectrin-like repeats and two Dbl homology (DH) domains that affect actin cytoskeletal dynamics via the small GTPases Rho and Rac. Phenotypic analysis demonstrates that trio and Abl cooperate in regulating axon outgrowth in the embryonic central nervous system (CNS). Dosage-sensitive interactions between trio and Abl, failed axon connections (fax), and enabled (ena) indicate that Trio is integrated into common signaling networks with these gene products. These observations suggest a mechanism by which Abl-mediated signaling networks influence the actin cytoskeleton in neuronal growth cones.
机译：Abelson酪氨酸激酶（Abl）已整合到调节轴突生长的信号转导网络中。我们已经通过加剧Abl突变表型的突变鉴定了果蝇三重基因。果蝇三重奏是哺乳动物三重奏的直系同源物，该蛋白包含多个血影蛋白样重复序列和两个Dbl同源（DH）域，这些域通过小的GTPases Rho和Rac影响肌动蛋白的细胞骨架动力学。表型分析表明，trio和Abl在调节胚胎中枢神经系统（CNS）的轴突生长中起着协同作用。 trio和Abl之间的剂量敏感相互作用，轴突连接失败（fax）和启用（ena）表明Trio与这些基因产物整合到常见的信号网络中。这些观察结果提示了Abl介导的信号网络影响神经元生长锥中肌动蛋白细胞骨架的机制。

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