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首页> 外文期刊>Neuron >The Stimulus Selectivity and Connectivity of Layer Six Principal Cells Reveals Cortical Microcircuits Underlying Visual Processing
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The Stimulus Selectivity and Connectivity of Layer Six Principal Cells Reveals Cortical Microcircuits Underlying Visual Processing

机译：第六层主细胞的刺激选择性和连通性揭示了视觉处理基础的皮质微电路

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摘要

Sensory computations performed in the neocortex involve layer six (L6) cortico-cortical (CC) and cortico-thalamic (CT) signaling pathways. Developing an understanding of the physiological role of these circuits requires dissection of the functional specificity and connectivity of the underlying individual projection neurons. By combining whole-cell recording from identified L6 principal cells in the mouse primary visual cortex (V1) with modified rabies virus-based input mapping, we have determined the sensory response properties and upstream monosynaptic connectivity of cells mediating the CC or CT pathway. We show that CC-projecting cells encompass a broad spectrum of selectivity to stimulus orientation and are predominantly innervated by deep layer V1 neurons. In contrast, CT-projecting cells are ultrasparse firing, exquisitely tuned to orientation and direction information, and receive long-range input from higher cortical areas. This segregation in function and connectivity indicates that L6 microcircuits route specific contextual and stimulus-related information within and outside the cortical network.
机译：在新皮层中进行的感觉计算涉及第六层（L6）皮层皮质（CC）和皮层丘脑（CT）信号通路。要了解这些回路的生理作用，就需要剖析潜在的单个投射神经元的功能特异性和连通性。通过将小鼠初级视觉皮层（V1）中已识别的L6主细胞的全细胞记录与基于改良的狂犬病病毒的输入映射相结合，我们确定了介导CC或CT途径的细胞的感觉反应特性和上游单突触连接性。我们显示，CC投射细胞涵盖了广泛的选择性的刺激方向，主要由深层V1神经元支配。相比之下，CT投射细胞是超稀疏发射的，精确地调整了方向和方向信息，并从较高的皮质区域接收远程输入。功能和连接性上的这种隔离表明L6微型电路在皮质网络内外路由特定的上下文和刺激相关信息。

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