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首页> 外文期刊>Neuron >Clonally Related Forebrain Interneurons Disperse Broadly across Both Functional Areas and Structural Boundaries
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Clonally Related Forebrain Interneurons Disperse Broadly across Both Functional Areas and Structural Boundaries

机译：克隆相关的前脑神经元广泛分布在功能区域和结构边界上

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The medial ganglionic eminence (MGE) gives rise to the majority of mouse forebrain interneurons. Here, we examine the lineage relationship among MGE-derived interneurons using a replication-defective retroviral library containing a highly diverse set of DNA barcodes. Recovering the barcodes from the mature progeny of infected progenitor cells enabled us to unambiguously determine their respective lineal relationship. We found that clonal dispersion occurs across large areas of the brain and is not restricted by anatomical divisions. As such, sibling interneurons can populate the cortex, hippocampus striatum, and globus pallidus. The majority of interneurons appeared to be generated from asymmetric divisions of MGE progenitor cells, followed by symmetric divisions within the subventricular zone. Altogether, our findings uncover that lineage relationships do not appear to determine interneuron allocation to particular regions. As such, it is likely that clonally related interneurons have considerable flexibility as to the particular forebrain circuits to which they can contribute.
机译：内侧神经节隆起（MGE）引起大多数小鼠前脑神经元。在这里，我们使用复制缺陷型逆转录病毒文库检查了MGE衍生的中间神经元之间的谱系关系，该文库包含高度不同的DNA条码集。从受感染的祖细胞的成熟后代中恢复条形码，使我们能够明确确定它们各自的线性关系。我们发现克隆扩散发生在大脑的大部分区域，不受解剖结构的限制。因此，同胞间神经元可以填充皮质，海马纹状体和苍白球。中间神经元的大多数似乎是由MGE祖细胞的不对称分裂产生的，随后是脑室下区域内的对称分裂。总而言之，我们的发现揭示了谱系关系似乎并不能确定中间神经元对特定区域的分配。这样，与克隆相关的中间神经元可能对它们可以贡献的特定前脑回路具有相当大的灵活性。

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