Unravelling Spinal Circuits of Pain and Mechanical Allodynia

Gangadharan Vijayan; Kuner Rohini

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Unravelling Spinal Circuits of Pain and Mechanical Allodynia

机译：解开脊柱回路的疼痛和机械性异常性疼痛

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How do spinal circuits mediating tactile sensation and pain get entangled to evoke allodynia, i.e., pain sensation, in response to a normally innocuous stimulus? Recent breakthroughs are now closing this long-standing, critical gap. VGLUT3-expressing neurons and their polysynaptic connectivity to calretinin-expressing neurons are now identified as key determinants of the spinal circuitry underlying mechanical allodynia.

机译：响应于通常无害的刺激，介导触觉和疼痛的脊髓回路如何纠缠以引起异常性疼痛，即疼痛感？最近的突破现在正在缩小这一长期存在的关键差距。现在已确定表达VGLUT3的神经元及其与表达钙调蛋白的神经元的多突触连接性是机械性异常性疼痛背后的脊髓回路的关键决定因素。

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《Neuron》 |2015年第4期|共3页
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Gangadharan Vijayan; Kuner Rohini;
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中图分类神经病学;
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1. Unravelling Spinal Circuits of Pain and Mechanical Allodynia [J] . Gangadharan Vijayan, Kuner Rohini Neuron . 2015,第4期

机译：解开脊柱回路的疼痛和机械性异常性疼痛
2. A peptide c-Jun N-terminal kinase (JNK) inhibitor blocks mechanical allodynia after spinal nerve ligation: respective roles of JNK activation in primary sensory neurons and spinal astrocytes for neuropathic pain development and maintenance. [J] . Zhuang ZY, Wen YR, Zhang DR, The Journal of Neuroscience: The Official Journal of the Society for Neuroscience . 2006,第13期

机译：肽c-Jun N端激酶（JNK）抑制剂可阻断脊髓神经结扎后的机械性异常性疼痛：JNK激活在初级感觉神经元和脊髓星形胶质细胞中对神经性疼痛的发生和维持的作用。
3. A feed-forward spinal cord glycinergic neural circuit gates mechanical allodynia [J] . Yan Lu, Hailong Dong, Yandong Gao, The journal of clinical investigation . 2013,第9期

机译：前馈脊髓甘氨酸能神经回路控制机械性异常性疼痛
4. An MRI-compatible and quantifiable mechanical stimulator for allodynia in a rat model of neuropathic pain [C] . Suzuki Toshiki, Dongmin Kim, Nagase Masae, Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2015

机译：MRI兼容且可量化的机械刺激器，用于神经性疼痛大鼠模型中的异常性疼痛
5. Defining the role of mechanical signals during nerve root compression in the development of sustained pain and neurophysiological correlates that develop in the injured tissue and spinal cord. [D] . Nicholson, Kristen J. 2013

机译：定义机械信号在神经根受压期间在持续性疼痛发展中的作用，以及在受伤组织和脊髓中发展的神经生理相关性。
6. A Peptide c-Jun N-Terminal Kinase (JNK) Inhibitor Blocks Mechanical Allodynia after Spinal Nerve Ligation: Respective Roles of JNK Activation in Primary Sensory Neurons and Spinal Astrocytes for Neuropathic Pain Development and Maintenance [O] . Zhi-Ye Zhuang, Yeong-Ray Wen, De-Ren Zhang, 2006

机译：肽c-Jun N末端激酶（JNK）抑制剂阻断脊髓神经结扎后的机械性异常性疼痛：JNK激活在原发性感觉神经元和脊髓星形胶质细胞对于神经性疼痛发展和维持中的各自作用。
7. Unravelling Spinal Circuits of Pain and Mechanical Allodynia [O] . Gangadharan Vijayan, Kuner Rohini 2015

机译：解开脊柱回路的疼痛和机械性异常性疼痛

Unravelling Spinal Circuits of Pain and Mechanical Allodynia

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