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Epigenetics of Stress-Related Psychiatric Disorders and Gene x Environment Interactions

机译：与精神压力有关的精神疾病的表观遗传学和基因x环境的相互作用

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摘要

A deeper understanding of the pathomechanisms leading to stress-related psychiatric disorders is important for the development of more efficient preventive and therapeutic strategies. Epidemiological studies indicate a combined contribution of genetic and environmental factors in the risk for disease. The environment, particularly early life severe stress or trauma, can lead to lifelong molecular changes in the form of epigenetic modifications that can set the organism off on trajectories to health or disease. Epigenetic modifications are capable of shaping and storing the molecular response of a cell to its environment as a function of genetic predisposition. This provides a potential mechanism for gene-environment interactions. Here, we review epigenetic mechanisms associated with the response to stress and trauma exposure and the development of stress-related psychiatric disorders. We also look at how they may contribute to our understanding of the combined effects of genetic and environmental factors in shaping disease risk.
机译：对导致与压力有关的精神疾病的发病机理的更深入了解对于开发更有效的预防和治疗策略很重要。流行病学研究表明，遗传和环境因素共同导致了疾病风险。环境，特别是生命早期的严重压力或创伤，可能导致表观遗传修饰形式的终生分子变化，从而使生物体陷入健康或疾病的轨道。表观遗传修饰能够根据遗传易感性来塑造和存储细胞对其环境的分子反应。这为基因-环境相互作用提供了潜在的机制。在这里，我们回顾了与压力和创伤暴露以及与压力有关的精神疾病的发展相关的表观遗传机制。我们还将研究它们如何有助于我们理解遗传和环境因素共同影响疾病风险的形成。

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