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Divisions of Identified Parvalbumin-Expressing Basket Cells during Working Memory-Guided Decision Making

机译:工作记忆指导的决策过程中已识别的表达小白蛋白的篮子细胞的分裂

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摘要

Parvalbumin-expressing basket cells tightly control cortical networks and fire remarkably stereotyped during network oscillations and simple behaviors. How can these cells support multifaceted situations with different behavioral options and complex temporal sequences? We recorded from identified parvalbumin-expressing basket cells in prefrontal cortex of freelymoving rats performing a multidimensional delayed cue-matching-to-place task, juxtacellularly filled recorded neurons for unequivocal histological identification, and determined their activity during temporally structured task episodes, associative working-memory, and stimulus-guided choice behavior. We show that parvalbumin-expressing basket cells do not fire homogenously, but individual cells were recruited or inhibited during different task episodes. Firing of individual basket cells was correlated with amount of presynaptic VIP (vasoactive intestinal polypeptide)-expressing GABAergic input. Together with subsets of pyramidal neurons, activity of basket cells differentiated for sequential actions and stimulus-guided choice behavior. Thus, interneurons of the same cell type can be recruited into different neuronal ensembles with distinct firing patterns to support multi-layered cognitive computations.
机译:表达小白蛋白的篮状细胞紧密控制皮质网络,并在网络振荡和简单行为期间明显起火。这些单元如何支持具有不同行为选择和复杂时间序列的多方面情况?我们记录了自由移动的大鼠的前额叶皮层中表达的小白蛋白表达的篮子细胞,这些大鼠执行多维延迟提示匹配到位置任务,并通过细胞旁填充的记录神经元进行明确的组织学鉴定,并确定它们在时间结构性任务发作,相关工作中的活动记忆力和刺激引导的选择行为。我们显示表达小白蛋白的篮子细胞不能均匀激发,但是在不同的任务发作期间单个细胞被募集或抑制。单个篮子细胞的生火与表达突触前VIP(血管活性肠多肽)的GABA能输入有关。连同锥体神经元的子集,篮子细胞的活动区分为顺序动作和刺激引导的选择行为。因此,可以将具有相同细胞类型的中间神经元募集到具有不同激发模式的不同神经元集合中,以支持多层认知计算。

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