Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.

Cheng HJ; Bagri A; Yaron A; Stein E; Pleasure SJ; Tessier-Lavigne M

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Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.

机译：Plexin-A3介导信号量信号并调节海马轴突投影的发展。

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Plexins are receptors implicated in mediating signaling by semaphorins, a family of axonal chemorepellents. The role of specific plexins in mediating semaphorin function in vivo has not, however, yet been examined in vertebrates. Here, we show that plexin-A3 is the most ubiquitously expressed plexin family member within regions of the developing mammalian nervous system known to contain semaphorin-responsive neurons. Using a chimeric receptor construct, we provide evidence that plexin-A3 can transduce a repulsive signal in growth cones in vitro. Analysis of plexin-A3 knockout mice shows that plexin-A3 contributes to Sema3F and Sema3A signaling and that plexin-A3 regulates the development of hippocampal axonal projections in vivo.

机译：丛蛋白是与信号量有关的受体，信号量是轴突化学驱除剂家族。然而，尚未在脊椎动物中检查特定的plexins在体内介导信号蛋白功能中的作用。在这里，我们显示plexin-A3是哺乳动物神经系统发育中区域中最普遍表达的plexin家族成员，已知该区域含有信号量响应神经元。使用嵌合受体构建体，我们提供的证据表明，plexin-A3可以在体外生长锥中转导排斥信号。对plexin-A3基因敲除小鼠的分析表明，plexin-A3有助于Sema3F和Sema3A信号传导，并且plexin-A3调节体内海马轴突投影的发展。

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《Neuron》 |2001年第2期|共15页
作者
Cheng HJ; Bagri A; Yaron A; Stein E; Pleasure SJ; Tessier-Lavigne M;
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正文语种 eng
中图分类神经生理学;
关键词
Axons; Glycoproteins; Hippocampus; Membrane Proteins; Nerve Tissue Proteins; 轴突; 糖蛋白类; 海马; 膜蛋白质类; 神经组织蛋白质类; 受体; 细胞表面; 信号传递;

机译：Axons;Glycoproteins;Hippocampus;Membrane Proteins;Nerve Tissue Proteins;轴突;糖蛋白类;海马;膜蛋白质类;神经组织蛋白质类;受体;细胞表面;信号传递;

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1. Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections. [J] . Cheng HJ, Bagri A, Yaron A, Neuron . 2001,第2期

机译：Plexin-A3介导信号量信号并调节海马轴突投影的发展。
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7. Plexin-A3 Mediates Semaphorin Signaling and Regulates the Development of Hippocampal Axonal Projections [O] . Cheng Hwai-Jong, Bagri Anil, Yaron Avraham, 2001

机译：Plexin-A3介导信号量信号并调节海马轴突投射的发展。

Plexin-A3 mediates semaphorin signaling and regulates the development of hippocampal axonal projections.

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