Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon.

Altrock WD; tom Dieck S; Sokolov M; Meyer AC; Sigler A; Brakebusch C; Fassler R; Richter K; Boeckers TM; Potschka H; Brandt C; Loscher W; Grimberg D; Dresbach T; Hempelmann A; Hassan H; Balschun D; Frey JU; Brandstatter JH; Garner CC; Rosenmund C; Gundelfinger ED

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Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon.

机译：缺乏活性区蛋白巴松的小鼠中一部分兴奋性突触的功能失活。

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Mutant mice lacking the central region of the presynaptic active zone protein Bassoon were generated to establish the role of this protein in the assembly and function of active zones as sites of synaptic vesicle docking and fusion. Our data show that the loss of Bassoon causes a reduction in normal synaptic transmission, which can be attributed to the inactivation of a significant fraction of glutamatergic synapses. At these synapses, vesicles are clustered and docked in normal numbers but are unable to fuse. Phenotypically, the loss of Bassoon causes spontaneous epileptic seizures. These data show that Bassoon is not essential for synapse formation but plays an essential role in the regulated neurotransmitter release from a subset of glutamatergic synapses.

机译：缺少突触前活性区蛋白Bassoon中心区域的突变小鼠被产生，以确立该蛋白在活性区的组装和功能中的作用，作为突触小泡对接和融合的位点。我们的数据表明，巴松管的丧失导致正常突触传递减少，这可以归因于大部分谷氨酸能突触的失活。在这些突触处，囊泡以正常数量聚集并停靠，但无法融合。从表型上来说，巴松管的丧失会导致自发性癫痫发作。这些数据表明，巴松管对于突触形成不是必需的，但在谷氨酸能突触的子集的调节的神经递质释放中起重要作用。

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《Neuron》 |2003年第5期|共14页
作者
Altrock WD; tom Dieck S; Sokolov M; Meyer AC; Sigler A; Brakebusch C; Fassler R; Richter K; Boeckers TM; Potschka H; Brandt C; Loscher W; Grimberg D; Dresbach T; Hempelmann A; Hassan H; Balschun D; Frey JU; Brandstatter JH; Garner CC; Rosenmund C; Gundelfinger ED;
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正文语种 eng
中图分类神经生理学;
关键词
Excitatory Postsynaptic Potentials; Gene Silencing physiology; Nerve Tissue Proteins; 兴奋性突触后电位; 神经组织蛋白质类; 突触;

机译：Excitatory Postsynaptic Potentials;Gene Silencing physiology;Nerve Tissue Proteins;兴奋性突触后电位;神经组织蛋白质类;突触;

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1. Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon. [J] . Altrock WD, tom Dieck S, Sokolov M, Neuron . 2003,第5期

机译：缺乏活性区蛋白巴松的小鼠中一部分兴奋性突触的功能失活。
2. Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses [J] . Andreas Fulterer, Till F.M. Andlauer, Anatoli Ender, Cell Reports . 2018,第5期

机译：活性区支架蛋白比率调节跨脑突触的功能多样性。
3. Morphological and metabolic changes in the cortex of mice lacking the functional presynaptic active zone protein bassoon: a combined 1H-NMR spectroscopy and histochemical study. [J] . Angenstein F, Hilfert L, Zuschratter W, Cerebral cortex . 2008,第4期

机译：缺少功能性突触前活性区蛋白巴松的小鼠皮质的形态和代谢变化：结合1H-NMR光谱和组织化学研究。
4. Quantitative Analysis of Brain Synaptic Plasma Membrane Proteins from DHA-Deficient and Adequate Mice Using ~(16)O/~(18)O Labeling [C] . Vishaldeep K. Sidhu, Bill Huang, Hee-Yong Kim American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2010

机译：使用〜（16）o /〜（18）o标记从DHA缺陷和足够小鼠中脑突触血浆膜蛋白的定量分析
5. Neurobehavioral impairments of prion protein deficient mice in olfactory tasks: Towards a functional understanding of the cellular prion protein PrP(C). [D] . Le Pichon, Claire. 2007

机译：嗅觉任务中的ion病毒蛋白缺陷小鼠的神经行为损害：对细胞病毒蛋白PrP（C）的功能性理解。
6. Active Zone Scaffold Protein Ratios Tune Functional Diversity across Brain Synapses [O] . Andreas Fulterer, Till F.M. Andlauer, Anatoli Ender, -1

机译：活性区支架蛋白比率调节跨脑突触的功能多样性。
7. Functional Inactivation of a Fraction of Excitatory Synapses in Mice Deficient for the Active Zone Protein Bassoon [O] . Altrock Wilko D., tom Dieck Susanne, Sokolov Maxim, 2003

机译：缺乏活性区蛋白巴松管的小鼠兴奋性突触部分的功能失活。

Functional inactivation of a fraction of excitatory synapses in mice deficient for the active zone protein bassoon.

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