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首页> 外文期刊>Neuron >Rapid development and plasticity of layer 2/3 maps in rat barrel cortex in vivo.
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Rapid development and plasticity of layer 2/3 maps in rat barrel cortex in vivo.

机译:体内大鼠桶状皮层中2/3层图的快速发展和可塑性。

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Cortical synaptic circuitry develops rapidly in the second postnatal week, simultaneous with experience-dependent turnover of dendritic spines. To relate the emergence of sensory maps to synaptogenesis, we recorded synaptic potentials evoked by whisker deflection in layer 2/3 neurons from postnatal day (P) 12 to 20. At P12, synaptic responses were undetectable. Only 2 days later in life (P14), receptive fields had mature organization. Sensory deprivation, if initiated before P14, disrupted receptive field structure. In layer 4, responses and maps were already mature by P12 and insensitive to deprivation, implying that barrel cortex develops from layer 4 to layer 2/3. Thus, P12-14 is a critical period shared by layer 2/3 synapses and their spines, suggesting that spine plasticity is involved in the refinement of maps.
机译:皮质突触回路在产后第二周迅速发展,同时伴随着经验依赖的树突棘翻转。为了将感觉图的出现与突触发生联系起来,我们记录了从出生后第12天到第20天由2/3层神经元晶须偏转引起的突触电位。在P12时,无法检测到突触反应。在生命中只有两天(P14),感受野具有成熟的组织。如果在P14之前引发感觉剥夺,则会破坏感受野结构。在第4层中,响应和映射已被P12成熟,并且对剥夺不敏感,这意味着桶状皮质从第4层发展到第2/3层。因此,P12-14是2/3层突触及其棘突共享的关键时期,表明脊柱可塑性参与了图谱的细化。

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