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首页> 外文期刊>Neuron >Neuronal Plasticity in Thalamocortical Networks during Sleep and Waking Oscillations.
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Neuronal Plasticity in Thalamocortical Networks during Sleep and Waking Oscillations.

机译：睡眠和清醒振荡期间丘脑皮质网络的神经元可塑性。

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摘要

Spontaneous brain oscillations during states of vigilance are associated with neuronal plasticity due to rhythmic spike bursts and spike trains fired by thalamic and neocortical neurons during low-frequency rhythms that characterize slow-wave sleep and fast rhythms occurring during waking and REM sleep. Intracellular recordings from thalamic and related cortical neurons in vivo demonstrate that, during natural slow-wave sleep oscillations or their experimental models, both thalamic and cortical neurons progressively enhance their responsiveness. This potentiation lasts for several minutes after the end of oscillatory periods. Cortical neurons display self-sustained activity, similar to responses evoked during previous epochs of stimulation, despite the fact that thalamic neurons remain under a powerful hyperpolarizing pressure. These data suggest that, far from being a quiescent state during which the cortex and subcortical structures are globally inhibited, slow-wave sleep may consolidate memory traces acquired during wakefulness in corticothalamic networks. Similar phenomena occur as a consequence of fast oscillations during brain-activated states.
机译：警惕状态下的自发性脑振荡与节律性突增爆发以及丘脑和新皮层神经元在低频节律以低频波节律为特征的神经元可塑性有关，低频节律的特征是慢波睡眠和苏醒和REM睡眠中发生的快速节律。体内丘脑和相关皮质神经元的细胞内记录表明，在自然慢波睡眠振荡或其实验模型期间，丘脑和皮质神经元均逐渐增强其反应能力。振荡周期结束后，这种增强作用持续几分钟。尽管丘脑神经元仍处于强大的超极化压力之下，但皮质神经元显示出自我维持的活性，类似于先前刺激时期引起的反应。这些数据表明，慢波睡眠不仅可以使皮质和皮层下结构受到整体抑制，而不会进入静止状态，而且可以巩固在皮质丘脑网络清醒过程中获得的记忆轨迹。在大脑激活状态期间，由于快速振荡而产生了类似的现象。

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