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首页> 外文期刊>Neuron >Spike Train Timing-Dependent Associative Modification of Hippocampal CA3 Recurrent Synapses by Mossy Fibers.
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Spike Train Timing-Dependent Associative Modification of Hippocampal CA3 Recurrent Synapses by Mossy Fibers.

机译：苔藓纤维海马CA3复发突触的穗火车时序依赖的关联修饰。

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摘要

In the CA3 region of the hippocampus, extensive recurrent associational/commissural (A/C) connections made by pyramidal cells may function as a network for associative memory storage and recall. We here report that long-term potentiation (LTP) at the A/C synapses can be induced by association of brief spike trains in mossy fibers (MFs) from the dentate gyrus and A/C fibers. This LTP not only required substantial overlap between spike trains in MFs and A/C fibers, but also depended on the temporal order of these spike trains in a manner not predicted by the well-known rule of spike timing-dependent plasticity and requiring activation of type 1 metabotropic glutamate receptors. Importantly, spike trains in a putative single MF input provided effective postsynaptic activity for the induction of LTP at A/C synapses. Thus, the timing of spike trains in individual MFs may code information that is crucial for the associative modification of CA3 recurrent synapses.
机译：在海马的CA3区，由锥体细胞建立的广泛的复发性联想/合子（A / C）连接可能充当联想记忆和回忆的网络。我们在这里报告，在A / C突触中的长期增强（LTP）可以通过齿状回和A / C纤维的苔藓纤维（MF）中的短暂尖峰序列的关联来诱导。这种LTP不仅需要在MF和A / C光纤中的尖峰序列之间存在实质性的重叠，而且还取决于这些尖峰序列的时间顺序，其方式不是由众所周知的与尖峰时间相关的可塑性规则所预测，并且需要激活1型代谢型谷氨酸受体。重要的是，假定的单个MF输入中的尖峰序列为在A / C突触中诱导LTP提供了有效的突触后活性。因此，单个MF中的尖峰序列的时序可能会编码对于CA3复发突触的相关修饰至关重要的信息。

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