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首页> 外文期刊>Neuron >Nonmonotonic synaptic excitation and imbalanced inhibition underlying cortical intensity tuning.
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Nonmonotonic synaptic excitation and imbalanced inhibition underlying cortical intensity tuning.

机译：非单调的突触兴奋和皮质强度调整背后的不平衡抑制。

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摘要

Intensity-tuned neurons, characterized by their nonmonotonic response-level function, may play important roles in the encoding of sound intensity-related information. The synaptic mechanisms underlying intensity tuning remain unclear. Here, in vivo whole-cell recordings in rat auditory cortex revealed that intensity-tuned neurons, mostly clustered in a posterior zone, receive imbalanced tone-evoked excitatory and inhibitory synaptic inputs. Excitatory inputs exhibit nonmonotonic intensity tuning, whereas with tone intensity increments, the temporally delayed inhibitory inputs increase monotonically in strength. In addition, this delay reduces with the increase of intensity, resulting in an enhanced suppression of excitation at high intensities and a significant sharpening of intensity tuning. In contrast, non-intensity-tuned neurons exhibit covaried excitatory and inhibitory inputs, and the relative time interval between them is stable with intensity increments, resulting in monotonic response-level function. Thus, cortical intensity tuning is primarily determined by excitatory inputs and shaped by cortical inhibition through a dynamic control of excitatory and inhibitory timing.
机译：以其非单调响应级功能为特征的强度调整神经元可能在与声音强度相关的信息的编码中发挥重要作用。强度调节的突触机制仍不清楚。在这里，在大鼠听觉皮层的体内全细胞记录显示，强度调节的神经元（主要聚集在后区）接收不平衡的音调诱发的兴奋性和抑制性突触输入。兴奋性输入表现出非单调的强度调整，而随着音调强度的增加，时间延迟的抑制性输入的强度会单调增加。另外，该延迟随着强度的增加而减小，从而导致在高强度下对激励的抑制得到增强，并且强度调整显着锐化。相反，非强度调整的神经元表现出兴奋性和抑制性输入的协变量，并且它们之间的相对时间间隔随强度的增加而稳定，从而导致单调响应级别的功能。因此，皮层强度的调节主要由兴奋性输入决定，并通过动态控制兴奋性和抑制性时机来抑制皮层强度。

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