• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Calcium signaling in dendrites and spines: practical and functional considerations.
【24h】

Calcium signaling in dendrites and spines: practical and functional considerations.

机译：树突和棘突中的钙信号传导：实用和功能考虑。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Changes in intracellular calcium (Ca) concentration following synaptic and suprathreshold activity are mediated by a wide range of sources and contribute to the regulation of myriad neuronal functions. The development of Ca imaging techniques has dramatically increased our understanding of the complex interactions between different Ca sources and their ability to produce spatial and temporal specificity of signaling, even within small cellular compartments such as dendrites and dendritic spines. However, as the use of Ca imaging has become more prevalent, the need to exercise care in the experimental methodology and interpretation of data has also grown. In this review, we discuss the recent progress made using imaging methods in understanding dendritic Ca signaling and also describe a quantitative framework for using fluorescent indicators to experimentally measure and interpret changes in intracellular Ca.
机译：突触和超阈活性后细胞内钙（Ca）浓度的变化由多种来源介导，并有助于调节多种神经元功能。 Ca成像技术的发展极大地增进了我们对不同Ca来源之间复杂相互作用的了解，以及它们甚至在小的细胞区室（例如树突和树突棘）中产生信号时空特异性的能力。但是，随着Ca成像的使用变得越来越普遍，在实验方法和数据解释中也需要谨慎行事。在这篇综述中，我们讨论了使用成像方法理解树突状钙信号的最新进展，并描述了使用荧光指示剂实验测量和解释细胞内钙变化的定量框架。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号