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首页> 外文期刊>Neuron >Temperature entrainment of Drosophila's circadian clock involves the gene nocte and signaling from peripheral sensory tissues to the brain.
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Temperature entrainment of Drosophila's circadian clock involves the gene nocte and signaling from peripheral sensory tissues to the brain.

机译：果蝇昼夜节律的温度夹带涉及基因夜蛾和从周围感觉组织到大脑的信号传导。

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摘要

Circadian clocks are synchronized by the natural dayight and temperature cycles. Our previous work demonstrated that synchronization by temperature is a tissue autonomous process, similar to synchronization by light. We show here that this is indeed the case, with the important exception of the brain. Using luciferase imaging we demonstrate that brain clock neurons depend on signals from peripheral tissues in order to be synchronized by temperature. Reducing the function of the gene nocte in chordotonal organs changes their structure and function and dramatically interferes with temperature synchronization of behavioral activity. Other mutants known to affect the function of these sensory organs also interfere with temperature synchronization, demonstrating the importance of nocte in this process and identifying the chordotonal organs as relevant sensory structures. Our work reveals surprising and important mechanistic differences between light- and temperature-synchronization and advances our understanding of how clock resetting is accomplished in nature.
机译：昼夜节律时钟通过自然的昼/夜和温度周期同步。我们以前的工作表明，温度同步是一个组织自主过程，类似于光同步。我们在这里表明，除了大脑的重要例外，情况确实如此。使用萤光素酶成像，我们证明了大脑时钟神经元依赖于周围组织的信号才能通过温度进行同步。降低软骨素器官中夜基因的功能会改变其结构和功能，并极大地干扰行为活动的温度同步。已知会影响这些感觉器官功能的其他突变体也会干扰温度同步，这证明了夜曲子在此过程中的重要性并将脊索神经器官识别为相关的感觉结构。我们的工作揭示了光同步和温度同步之间令人惊讶且重要的机制差异，并加深了我们对自然完成时钟重置的理解。

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