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首页> 外文期刊>Neuron >Synchronization of midbrain dopaminergic neurons is enhanced by rewarding events.
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Synchronization of midbrain dopaminergic neurons is enhanced by rewarding events.

机译：奖励事件可增强中脑多巴胺能神经元的同步。

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The basal ganglia network is divided into two functionally related subsystems: the neuromodulators and the main axis. It is assumed that neuromodulators adjust cortico-striatal coupling. This adjustment might depend on the response properties and temporal interactions between neuromodulators. We studied functional interactions between simultaneously recorded pairs of neurons in the basal ganglia while monkeys performed a classical conditioning task that included rewarding, neutral, and aversive events. Neurons that belong to a single neuromodulator group exhibited similar average responses, whereas main axis neurons responded in a highly diverse manner. Dopaminergic neuromodulators transiently increased trial-to-trial (noise) correlation following rewarding but not aversive events, whereas cholinergic neurons of the striatum decreased their trial-to-trial correlation. These changes in functional connectivity occurred at different epochs of the trial. Thus, the coding scheme of neuromodulators (but not main axis neurons) can be viewed as a single-dimensional code that is further enriched by dynamic neuronal interactions.
机译：基底神经节网络分为两个功能相关的子系统：神经调节剂和主轴。假定神经调节剂调节皮层-纹状体的耦合。这种调整可能取决于神经调节剂之间的反应特性和时间相互作用。我们研究了基底神经节中同时记录的成对神经元之间的功能相互作用，而猴子则执行了经典的调节任务，包括奖励，中立和厌恶事件。属于单个神经调节剂组的神经元表现出相似的平均响应，而主轴神经元以高度多样化的方式响应。多巴胺能神经调节剂在奖励但无厌恶事件后暂时增加试验与试验（噪声）的相关性，而纹状体的胆碱能神经元则降低其试验与试验的相关性。功能连接性的这些变化发生在试验的不同时期。因此，神经调节剂（而不是主轴神经元）的编码方案可以看作是一维代码，通过动态神经元相互作用进一步丰富。

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