Too fat to fly? New brain circuits regulate obesity in Drosophila.

Kaun KR; Heberlein U

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Too fat to fly? New brain circuits regulate obesity in Drosophila.

机译：太胖了吗？新的大脑回路调节果蝇肥胖。

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In mammals, fat store levels are regulated by brain centers that control food intake and metabolism. A new study by Al-Anzi and colleagues in this issue of Neuron identifies neurons with similar functions in Drosophila, further establishing the fly as a legitimate model to study obesity.

机译：在哺乳动物中，脂肪储存的水平由控制食物摄入和新陈代谢的大脑中枢调节。 Al-Anzi及其同事在本期《神经元》上的一项新研究发现了果蝇中具有相似功能的神经元，从而进一步将果蝇确立为研究肥胖症的合法模型。

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《Neuron》 |2009年第3期|共3页
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Kaun KR; Heberlein U;
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正文语种 eng
中图分类神经生理学;
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1. Too fat to fly? New brain circuits regulate obesity in Drosophila. [J] . Kaun KR, Heberlein U Neuron . 2009,第3期

机译：太胖了吗？新的大脑回路调节果蝇肥胖。
2. Cracking neural circuits in a tiny brain: new approaches for understanding the neural circuitry of Drosophila. [J] . Olsen SR, Wilson RI Trends in Neurosciences . 2008,第10期

机译：破解小脑中的神经回路：了解果蝇神经回路的新方法。
3. Depot- and obesity-related differences in adipogenesisAdipocyte hypertrophy and hyperplasia are known to facilitate lipid storage in adipose tissues by increasing adipocyte cell size and number, respectively. Adipogenesis is the process resulting in adipose tissue hyperplasia. Although depot-specific differences and obesity-related modulation of adipocyte size are well documented, available data on adipogenesis and adipose tissue hyperplasia are less conclusive. Most studies support a reduction of adipogenesis in the obese state. Preadipocytes of the subcutaneous fat depot appear to be more responsive to adipogenic stimulation compared with those from visceral fat compartments in most studies. A number of studies support the notion that adipose tissue expansion through hyperplasia reduces ectopic lipid excess and obesity-related complications. Several genetic variants have been identified in the genes coding for adipogenesis-regulating proteins. While some of these variants have been clearly associated with the phenotypes of obesity and obesity-related alterations, available data highlight the importance of considering gene–gene and gene–diet interactions. [J] . Julie. Lessard, André. Tchernof Clinical lipidology. . 2012,第5期

机译：脂肪形成与肥胖相关的差异已知脂肪细胞肥大和增生分别通过增加脂肪细胞的大小和数量来促进脂质在脂肪组织中的存储。脂肪形成是导致脂肪组织增生的过程。尽管已经有很多文献记载了贮库特异性差异和肥胖相关的脂肪细胞大小调节，但有关脂肪形成和脂肪组织增生的可用数据尚无定论。大多数研究支持在肥胖状态下减少脂肪形成。在大多数研究中，与来自内脏脂肪区室的脂肪细胞相比，皮下脂肪库的前脂肪细胞似乎对脂肪刺激更为敏感。许多研究支持这样的观点，即通过增生的脂肪组织扩张可以减少异位脂质过多和肥胖相关的并发症。在编码脂肪形成调节蛋白的基因中已经鉴定出几种遗传变异。尽管其中一些变异与肥胖症的表型和与肥胖有关的改变明显相关，但现有数据突出了考虑基因-基因和基因-饮食相互作用的重要性。
4. Self-Regulated Learning Differences between Obese and Non-Obese Adolescents: A Comparative Study of Senior High School Students in Medan City [C] . Fasti Rola, Ade Rahmawati Srg, Debby A. Daulay International Conference on Social and Political Development . 2018

机译：肥胖与非肥胖青少年之间的自我监管学习差异：棉兰城市高中生的比较研究
5. An Open Pipeline for Generating Executable Neural Circuits from Fruit Fly Brain Data. [D] . Givon, Lev E. 2016

机译：从果蝇大脑数据生成可执行神经回路的开放式管道。
6. Neural circuits mediating visual flight control in flies. II. Separation of two control systems by microsurgical brain lesions [O] . K Hausen, C Wehrhahn 1990

机译：神经回路介导果蝇的视觉飞行控制。二。通过脑部显微外科手术分离两个控制系统
7. Too Fat to Fly? New Brain Circuits Regulate Obesity in Drosophila [O] . Kaun Karla R., Heberlein Ulrike 2009

机译：太胖了不能飞？新的大脑回路调节果蝇肥胖

Too fat to fly? New brain circuits regulate obesity in Drosophila.

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