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首页> 外文期刊>Neuron >Cell-Targeted Optogenetics and Electrical Microstimulation Reveal the Primate Koniocellular Projection to Supra-granular Visual Cortex
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Cell-Targeted Optogenetics and Electrical Microstimulation Reveal the Primate Koniocellular Projection to Supra-granular Visual Cortex

机译：以细胞为靶标的光遗传学和电微刺激揭示灵长类动物单核细胞投射到粒上视觉皮层。

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Electrical microstimulation and more recently optogenetics are widely used to map large-scale brain circuits. However, the neuronal specificity achieved with both methods is not well understood. Here we compare cell-targeted optogenetics and electrical microstimulation in the macaque monkey brain to functionally map the koniocellular lateral geniculate nucleus (LGN) projection to primary visual cortex (V1). Selective activation of the LGN konio neurons with CamK-specific optogenetics caused selective electrical current inflow in the supra-granular layers of V1. Electrical microstimulation targeted at LGN konio layers revealed the same supra-granular V1 activation pattern as the one elicited by optogenetics. Taken together, these findings establish a selective koniocellular LGN influence on V1 supra-granular layers, and they indicate comparable capacities of both stimulation methods to isolate thalamo-cortical circuits in the primate brain.
机译：电微刺激和近来的光遗传学被广泛用于绘制大规模脑电路图。然而，两种方法实现的神经元特异性尚不十分清楚。在这里，我们比较了猕猴脑中细胞靶向的光遗传学和电微刺激，以功能性地将koniocellular外侧膝状核（LGN）投影映射到初级视觉皮层（V1）。具有CamK特异性光遗传学的LGN konio神经元的选择性激活导致V1的超颗粒层中选择性的电流流入。针对LGN konio层的电微刺激显示出与光遗传学引发的相同的超颗粒V1激活模式。综上所述，这些发现建立了对V1颗粒上层的选择性konocyte红细胞LGN的影响，并且它们表明两种刺激方法在灵长类动物大脑中隔离丘脑-皮质回路的能力相当。

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