Bifocal Is a Downstream Target of the Ste20-like Serine/Threonine Kinase Misshapen in Regulating Photoreceptor Growth Cone Targeting in Drosophila.

Ruan W; Long H; Vuong DH; Rao Y

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Bifocal Is a Downstream Target of the Ste20-like Serine/Threonine Kinase Misshapen in Regulating Photoreceptor Growth Cone Targeting in Drosophila.

机译：双焦点是Ste20样丝氨酸/苏氨酸激酶激酶失调的下游靶标，可调控果蝇中的感光细胞生长锥。

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Misshapen (Msn) has been proposed to shut down Drosophila photoreceptor (R cell) growth cone motility in response to targeting signals linked by the SH2/SH3 adaptor protein Dock. Here, we show that Bifocal (Bif), a putative cytoskeletal regulator, is a component of the Msn pathway for regulating R cell growth cone targeting. bif displays strong genetic interaction with msn. Phenotypic analysis indicates a specific role for Bif to terminate R1-R6 growth cones. Biochemical studies show that Msn associates directly with Bif and phosphorylates Bif in vitro. Cell culture studies demonstrate that Msn interacts with Bif to regulate F-actin structure and filopodium formation. We propose that Bif functions downstream of Msn to reorganize actin cytoskeleton in decelerating R cell growth cone motility at the target region.

机译：有人提议Misshapen（Msn）关闭果蝇感光细胞（R细胞）的生长锥运动，以响应由SH2 / SH3衔接子蛋白坞连接的靶向信号。在这里，我们显示了Bifocal（Bif），一种假定的细胞骨架调节剂，是Msn途径中调节R细胞生长锥靶向的成分。 bif与msn表现出强大的遗传相互作用。表型分析表明Bif终止R1-R6生长锥的特定作用。生化研究表明，Msn与Bif直接缔合，并在体外使Bif磷酸化。细胞培养研究表明，Msn与Bif相互作用以调节F-肌动蛋白的结构和纤毛的形成。我们建议Bif功能的Msn下游重组肌动蛋白细胞骨架在减速R细胞生长锥运动在目标区域。

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《Neuron》 |2002年第5期|共12页
作者
Ruan W; Long H; Vuong DH; Rao Y;
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正文语种 eng
中图分类神经生理学;
关键词
Growth Cones; Photoreceptors; Drosophila; motility; 生长锥; 光感受器; 果蝇属;

机译：Growth Cones;Photoreceptors;Drosophila;motility;生长锥;光感受器;果蝇属;

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1. Bifocal Is a Downstream Target of the Ste20-like Serine/Threonine Kinase Misshapen in Regulating Photoreceptor Growth Cone Targeting in Drosophila. [J] . Ruan W, Long H, Vuong DH, Neuron . 2002,第5期

机译：双焦点是Ste20样丝氨酸/苏氨酸激酶激酶失调的下游靶标，可调控果蝇中的感光细胞生长锥。
2. The Ste20 Kinase Misshapen Regulates Both Photoreceptor Axon Targeting and Dorsal Closure, Acting Downstream of Distinct Signals [J] . Yi-Chi Su, Corinne Maurel-Zaffran, Jessica E. Treisman, Molecular and Cellular Biology . 2000,第13期

机译：Ste20激酶失调调节了受体的轴突和背封闭，在不同信号的下游起作用。
3. Bifocal and PP1 interaction regulates targeting of the R-cell growth cone in Drosophila. [J] . Babu K, Bahri S, Alphey L, Developmental biology . 2005,第2期

机译：双焦点和PP1相互作用调节果蝇中R细胞生长锥的靶向。
4. GmWNK1, a Novel Serine/ Threonine Protein Kinase in Soybean Roots, Regulates ABA-Dependent Osmotic Stresses in Plants [C] . Yingxiang Wang, Kaidong Liu, Hong Liao, The 7th International Symposium on Plant-Soil Interactions at Low pH（第七届低pH条件下植物-土壤交互作用国际研讨会） . 2009

机译：GmWNK1，大豆根中的一种新型丝氨酸/苏氨酸蛋白激酶，调节植物中依赖ABA的渗透胁迫
5. Regulation of pancreatic beta cell growth, function, and survival by the serine/threonine protein kinase Akt1/Pkb alpha. [D] . Tuttle, Robyn Lynn. 2002

机译：丝氨酸/苏氨酸蛋白激酶Akt1 / Pkbα对胰腺β细胞生长，功能和存活的调节。
6. The Ste20 Kinase Misshapen Regulates Both Photoreceptor Axon Targeting and Dorsal Closure Acting Downstream of Distinct Signals [O] . Yi-Chi Su, Corinne Maurel-Zaffran, Jessica E. Treisman, 2000

机译：Ste20激酶失调调节了受体的轴突和背闭合同时作用于不同信号的下游。
7. Bifocal Is a Downstream Target of the Ste20-like Serine/Threonine Kinase Misshapen in Regulating Photoreceptor Growth Cone Targeting in Drosophila [O] . Ruan Wenjing, Long Hong, Vuong Dac Hien, 2002

机译：双焦点是Ste20样丝氨酸/苏氨酸激酶激酶失调的下游靶标，调控果蝇中的感光细胞生长锥。

Bifocal Is a Downstream Target of the Ste20-like Serine/Threonine Kinase Misshapen in Regulating Photoreceptor Growth Cone Targeting in Drosophila.

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