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首页> 外文期刊>Neuron >Cytoskeletal dynamics and transport in growth cone motility and axon guidance.
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Cytoskeletal dynamics and transport in growth cone motility and axon guidance.

机译:细胞骨架动力学和运输中生长锥运动和轴突的指导。

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摘要

Recent studies indicate the actin and microtubule cytoskeletons are a final common target of many signaling cascades that influence the developing neuron. Regulation of polymer dynamics and transport are crucial for the proper growth cone motility. This review addresses how actin filaments, microtubules, and their associated proteins play crucial roles in growth cone motility, axon outgrowth, and guidance. We present a working model for cytoskeletal regulation of directed axon outgrowth. An important goal for the future will be to understand the coordinated response of the cytoskeleton to signaling cascades induced by guidance receptor activation.
机译:最近的研究表明,肌动蛋白和微管细胞骨架是影响发育中神经元的许多信号级联的最终共同目标。聚合物动力学和运输的调节对于适当的生长锥运动至关重要。这项审查解决肌动蛋白丝,微管及其相关蛋白如何在生长锥运动,轴突生长和指导中发挥关键作用。我们提出了针对定向轴突生长的细胞骨架调节的工作模型。未来的重要目标将是了解细胞骨架对由指导受体激活诱导的信号级联反应的协同反应。

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