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首页> 外文期刊>Neuron >Narp and NP1 form heterocomplexes that function in developmental and activity-dependent synaptic plasticity.
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Narp and NP1 form heterocomplexes that function in developmental and activity-dependent synaptic plasticity.

机译：Narp和NP1形成杂合体，在发育和活动依赖性突触可塑性中起作用。

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Narp is a neuronal immediate early gene that plays a role in excitatory synaptogenesis. Here, we report that native Narp in brain is part of a pentraxin complex that includes NP1. These proteins are covalently linked by disulfide bonds into highly organized complexes, and their relative ratio in the complex is dynamically dependent upon the neuron's activity history and developmental stage. Complex formation is dependent on their distinct N-terminal coiled-coil domains, while their closely homologous C-terminal pentraxin domains mediate association with AMPA-type glutamate receptors. Narp is substantially more effective in assays of cell surface cluster formation, coclustering of AMPA receptors, and excitatory synaptogenesis, yet their combined expression results in supraadditive effects. These studies support a model in which Narp can regulate the latent synaptogenic activity of NP1 by forming mixed pentraxin assemblies. This mechanism appears to contribute to both activity-independent and activity-dependent excitatory synaptogenesis.
机译：Narp是一种神经元立即早期基因，在兴奋性突触发生中起作用。在这里，我们报告说，大脑中的天然Narp是包含NP1的pentraxin复合物的一部分。这些蛋白质通过二硫键共价连接成高度组织化的复合物，它们在复合物中的相对比例动态取决于神经元的活动历史和发育阶段。复合物的形成取决于它们独特的N末端卷曲螺旋结构域，而其紧密同源的C末端五环毒素域介导与AMPA型谷氨酸受体的缔合。 Narp在检测细胞表面簇形成，AMPA受体的共簇化和兴奋性突触形成方面显着更有效，但它们的联合表达可产生超加和效应。这些研究支持一种模型，其中Narp可以通过形成混合的五环素装配体来调节NP1的潜在突触活性。这种机制似乎有助于活动独立和活动依赖的兴奋性突触发生。

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