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首页> 外文期刊>Neuron >SOX2 functions to maintain neural progenitor identity.
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SOX2 functions to maintain neural progenitor identity.

机译：SOX2的功能是维持神经祖细胞的身份。

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摘要

Neural progenitors of the vertebrate CNS are defined by generic cellular characteristics, including their pseudoepithelial morphology and their ability to divide and differentiate. SOXB1 transcription factors, including the three closely related genes Sox1, Sox2, and Sox3, universally mark neural progenitor and stem cells throughout the vertebrate CNS. We show here that constitutive expression of SOX2 inhibits neuronal differentiation and results in the maintenance of progenitor characteristics. Conversely, inhibition of SOX2 signaling results in the delamination of neural progenitor cells from the ventricular zone and exit from cell cycle, which is associated with a loss of progenitor markers and the onset of early neuronal differentiation markers. The phenotype elicited by inhibition of SOX2 signaling can be rescued by coexpression of SOX1, providing evidence for redundant SOXB1 function in CNS progenitors. Taken together, these data indicate that SOXB1 signaling is both necessary and sufficient to maintain panneural properties of neural progenitor cells.
机译：脊椎动物CNS的神经祖细胞由通用的细胞特征定义，包括其伪上皮形态及其分裂和分化能力。 SOXB1转录因子，包括三个紧密相关的基因Sox1，Sox2和Sox3，普遍标记了整个脊椎动物CNS中的神经祖细胞和干细胞。我们在这里显示SOX2的组成型表达抑制神经元分化，并导致祖细胞特征的维持。相反，对SOX2信号的抑制导致神经祖细胞从心室区分层并退出细胞周期，这与祖细胞标记的丢失和早期神经元分化标记的发作有关。可以通过共表达SOX1来挽救因抑制SOX2信号而引起的表型，从而为中枢神经系统祖细胞中多余的SOXB1功能提供了证据。综上所述，这些数据表明SOXB1信号传导对于维持神经祖细胞的神经系统特性既必要又充分。

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