A G protein-coupled receptor, groom-of-PDF, is required for PDF neuron action in circadian behavior.

Lear BC; Merrill CE; Lin JM; Schroeder A; Zhang L; Allada R

首页> 外文期刊>Neuron >A G protein-coupled receptor, groom-of-PDF, is required for PDF neuron action in circadian behavior.

【24h】

A G protein-coupled receptor, groom-of-PDF, is required for PDF neuron action in circadian behavior.

机译：昼夜节律行为中PDF神经元的作用需要一个G蛋白偶联受体，即PDF。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

The neuropeptide Pigment-Dispersing Factor (PDF) plays a critical role in mediating circadian control of behavior in Drosophila. Here we identify mutants (groom-of-PDF; gop) that display phase-advanced evening activity and poor free-running rhythmicity, phenocopying pdf mutants. In gop mutants, a spontaneous retrotransposon disrupts a coding exon of a G protein-coupled receptor, CG13758. Disruption of the receptor is accompanied by phase-advanced oscillations of the core clock protein PERIOD. Moreover, effects on circadian timing induced by perturbation of PDF neurons require gop. Yet PDF oscillations themselves remain robust in gop mutants, suggesting that GOP acts downstream of PDF. gop is expressed most strongly in the dorsal brain in regions that lie in proximity to PDF-containing nerve terminals. Taken together, these studies implicate GOP as a PDF receptor in Drosophila.

机译：神经肽色素分散因子（PDF）在介导果蝇的昼夜节律行为控制中起关键作用。在这里，我们确定了突变体（PDF修饰; gop），这些突变体表现出阶段性的夜间活动和表现出较差的自律性，表型为pdf突变体。在gop突变体中，自发逆转录转座子破坏了G蛋白偶联受体CG13758的编码外显子。受体的破坏伴随着核心时钟蛋白PERIOD的相位提前振荡。此外，PDF神经元的扰动对昼夜节律的影响需要gop。然而，在gop突变体中，PDF振荡本身仍然很健壮，这表明GOP在PDF的下游起作用。 gop在背侧大脑中靠近包含PDF的神经末梢的区域表达最强烈。综上所述，这些研究表明果蝇中GOP是PDF受体。

著录项

来源
《Neuron》 |2005年第2期|共7页
作者
Lear BC; Merrill CE; Lin JM; Schroeder A; Zhang L; Allada R;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
receptor; behavioral aspects; GTP-Binding Proteins; Neurons; Drosophila; GTP-结合蛋白质类; 神经元; 果蝇属;

机译：receptor;behavioral aspects;GTP-Binding Proteins;Neurons;Drosophila;GTP-结合蛋白质类;神经元;果蝇属;

相似文献

外文文献
中文文献
专利

1. A G protein-coupled receptor, groom-of-PDF, is required for PDF neuron action in circadian behavior. [J] . Lear BC, Merrill CE, Lin JM, Neuron . 2005,第2期

机译：昼夜节律行为中PDF神经元的作用需要一个G蛋白偶联受体，即PDF。
2. Autoreceptor Control of Peptide/Neurotransmitter Corelease from PDF Neurons Determines Allocation of Circadian Activity in Drosophila [J] . Charles Choi, Guan Cao, Anne K. Tanenhaus, Cell Reports . 2012,第2期

机译：PDF神经元的肽/神经递质共释放的自受体控制确定果蝇中昼夜活动的分配。
3. Heterotrimeric guanosine triphosphate-binding protein-coupled modulatory actions of motilin on K+ channels and postsynaptic ??-aminobutyric acid receptors in mouse medial vestibular nuclear neurons [J] . TodakaH., TatsukawaT., HashikawaT., The European Journal of Neuroscience . 2013,第3a4期

机译：异三聚体鸟嘌呤三磷酸结合蛋白结合的胃动素对小鼠内侧前庭核神经元中K +通道和突触后β-氨基丁酸受体的调节作用
4. A Novel Strategy for Prediction of Cellular Cholesterol Signature Motif from G Protein-Coupled Receptors based on Rough Set and FCM Algorithm [C] . Rudra Kalyan Nayak, Ramamani Tripathy, Saravanan V, International Conference on Computing Methodologies and Communication . 2020

机译：基于粗糙集和FCM算法的G蛋白偶联受体预测细胞胆固醇信号基序的新策略
5. Protein interactions mediating endocytic recycling of G protein-coupled receptors. [D] . Lauffer, Benjamin E.L. 2008

机译：蛋白质相互作用介导G蛋白偶联受体的内吞再循环。
6. E AND M CIRCADIAN PACEMAKER NEURONS USE DIFFERENT PDF RECEPTOR SIGNALOSOME COMPONENTS IN DROSOPHILA [O] . Laura B. Duvall, Paul H. Taghert -1

机译：E和M克尔凯第神经系统的神经元在果蝇中使用不同的PDF受体信号成分
7. A G Protein-Coupled Receptor, groom-of-PDF, Is Required for PDF Neuron Action in Circadian Behavior [O] . Lear Bridget C., Merrill C. Elaine, Lin Jui-Ming, 2005

机译：PDF在昼夜节律行为中的神经元作用需要一个G蛋白偶联受体，PDF修饰体

A G protein-coupled receptor, groom-of-PDF, is required for PDF neuron action in circadian behavior.

摘要

著录项

相似文献

相关主题

期刊订阅