Arc/Arg3.1: linking gene expression to synaptic plasticity and memory.

Tzingounis AV; Nicoll RA

首页> 外文期刊>Neuron >Arc/Arg3.1: linking gene expression to synaptic plasticity and memory.

【24h】

Arc/Arg3.1: linking gene expression to synaptic plasticity and memory.

机译：Arc / Arg3.1：将基因表达与突触可塑性和记忆联系起来。

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Arc/Arg3.1 is an effector immediate-early gene implicated in the consolidation of memories. Although cloned a decade ago, the physiological role of Arc/Arg3.1 in the brain has remained elusive. Four papers in this issue of Neuron address this function. These studies show that Arc/Arg3.1 regulates endophilin 3 and dynamin 2, two components of the endocytosis machinery. Genetic ablation of Arc/Arg3.1 in mice or overexpression in culture suggest that Arc/Arg3.1 regulates AMPA receptor trafficking and synaptic plasticity. Finally, Arc/Arg3.1 knockout mice show memory retention deficits. These recent developments provide new insights into the function of this popular activity-dependent neuronal marker.

机译：Arc / Arg3.1是与记忆整合有关的效应基因。尽管在十年前被克隆，但是Arc / Arg3.1在大脑中的生理作用仍然难以捉摸。在本期《神经元》中有四篇论文探讨了这一功能。这些研究表明，Arc / Arg3.1调节内吞蛋白3和动力蛋白2，它们是内吞作用机器的两个组成部分。小鼠中Arc / Arg3.1的遗传消融或培养物中的过度表达表明Arc / Arg3.1调节AMPA受体的转运和突触可塑性。最后，Arc / Arg3.1基因敲除小鼠显示记忆力保持不足。这些最新发展为这种流行的依赖活动的神经元标记物的功能提供了新的见解。

著录项

来源
《Neuron》 |2006年第3期|共5页
作者
Tzingounis AV; Nicoll RA;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类神经生理学;
关键词
Cytoskeletal Proteins; Gene Expression; Memory; Nerve Tissue Proteins; Neuronal Plasticity; 细胞支架蛋白质类; 基因表达; 记忆; 神经组织蛋白质类; 神经元可塑性;

机译：Cytoskeletal Proteins;Gene Expression;Memory;Nerve Tissue Proteins;Neuronal Plasticity;细胞支架蛋白质类;基因表达;记忆;神经组织蛋白质类;神经元可塑性;

相似文献

外文文献
中文文献
专利

1. Arc/Arg3.1: linking gene expression to synaptic plasticity and memory. [J] . Tzingounis AV, Nicoll RA Neuron . 2006,第3期

机译：Arc / Arg3.1：将基因表达与突触可塑性和记忆联系起来。
2. Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission. [J] . Rial-Verde EM, Lee-Osbourne J, Worley PF, Neuron . 2006,第3期

机译：立即早期基因arc / arg3.1的表达增加减少了AMPA受体介导的突触传递。
3. Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. [J] . Alberi L, Liu S, Wang Y, Neuron . 2011,第3期

机译：神经元中活动诱导的Notch信号传导需要Arc / Arg3.1，对于海马网络中的突触可塑性至关重要。
4. Function of Prothymosin α in Chromatin Decondensation and Expression of Thymosin β-4 Linked to Angiogenesis and Synaptic Plasticity [C] . JAIME GOMEZ-MARQUEZ International Symposiumn on Thymosins in Health and Disease; 20070321-24; Washington,DC(US) . 2007

机译：胸腺素α在染色质浓缩和胸腺素β-4表达中的作用与血管生成和突触可塑性有关
5. Spatial Regulation of Gene Expression in Neurons During Synapse Formation and Synaptic Plasticity [D] . Kim, Sangmok 2013

机译：突触形成和突触可塑性过程中神经元中基因表达的空间调节。
6. Position- and Time-Dependent Arc Expression Links Neuronal Activity to Synaptic Plasticity During Epileptogenesis [O] . Philipp Janz, Pascal Hauser, Katharina Heining, 2018

机译：位置和时间依赖的弧表达将癫痫发生过程中神经元活动链接到突触可塑性。
7. Arc/Arg3.1: Linking Gene Expression to Synaptic Plasticity and Memory [O] . Tzingounis Anastassios V., Nicoll Roger A. 2006

机译：Arc / Arg3.1：将基因表达与突触可塑性和记忆联系起来

Arc/Arg3.1: linking gene expression to synaptic plasticity and memory.

摘要

著录项

相似文献

相关主题

期刊订阅