• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb.
【24h】

Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb.

机译：GDNF / Ret和ephrinA / EphA4信号之间的协作，用于肢体运动轴突途径选择。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Establishment of limb innervation by motor neurons involves a series of hierarchical axon guidance decisions by which motor-neuron subtypes evaluate peripheral guidance cues and choose their axonal trajectory. Earlier work indicated that the pathway into the dorsal limb by lateral motor column (LMC[l]) axons requires the EphA4 receptor, which mediates repulsion elicited by ephrinAs expressed in ventral limb mesoderm. Here, we implicate glial-cell-line-derived neurotrophic factor (GDNF) and its receptor, Ret, in the same guidance decision. In Gdnf or Ret mutant mice, LMC(l) axons follow an aberrant ventral trajectory away from dorsal territory enriched in GDNF, showing that the GDNF/Ret system functions as an instructive guidance signal for motor axons. This phenotype is enhanced in mutant mice lacking Ret and EphA4. Thus, Ret and EphA4 signals cooperate to enforce the precision of the same binary choice in motor-axon guidance.
机译：运动神经元建立肢体神经支配涉及一系列分级的轴突指导决策，通过这些决策，运动神经元亚型评估周围的指导线索并选择其轴突轨迹。较早的工作表明，通过外侧运动柱（LMC [l]）轴突进入背肢的途径需要EphA4受体，该受体介导由在腹肢中胚层中表达的ephrinA引起的排斥。在这里，我们将神经胶质细胞系衍生的神经营养因子（GDNF）及其受体Ret包含在同一指导决策中。在Gdnf或Ret突变小鼠中，LMC（1）轴突遵循异常的腹侧轨迹，远离富含GDNF的背侧区域，显示GDNF / Ret系统可作为运动轴突的指导信号。这种表型在缺少Ret和EphA4的突变小鼠中得到增强。因此，Ret和EphA4信号协同作用以增强电机轴突制导中相同二进制选择的精度。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号