...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >A role for Nogo receptor in macrophage clearance from injured peripheral nerve.
【24h】

A role for Nogo receptor in macrophage clearance from injured peripheral nerve.

机译：Nogo受体在从受损的周围神经清除巨噬细胞中的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We report a role for Nogo receptors (NgRs) in macrophage efflux from sites of inflammation in peripheral nerve. Increasing numbers of macrophages in crushed rat sciatic nerves express NgR1 and NgR2 on the cell surface in the first week after injury. These macrophages show reduced binding to myelin and MAG in vitro, which is reversed by NgR siRNA knockdown and by inhibiting Rho-associated kinase. Fourteen days after sciatic nerve crush, regenerating nerves with newly synthesized myelin have fewer macrophages than cut/ligated nerves that lack axons and myelin. Almost all macrophages in the cut/ligated nerves lie within the Schwann cell basal lamina, while in the crushed regenerating nerves the majority migrate out. Furthermore, crush-injured nerves of NgR1- and MAG-deficient mice and Y-27632-treated rats show impaired macrophage efflux from Schwann cell basal lamina containing myelinated axons. These data have implications for the resolution of inflammation in peripheral nerve and CNS pathologies.
机译：我们报告巨噬细胞外流发炎周围神经中的Nogo受体（NgRs）的作用。损伤后第一周，越来越多的大鼠坐骨神经压迫巨噬细胞在细胞表面表达NgR1和NgR2。这些巨噬细胞在体外显示出与髓磷脂和MAG的结合减少，这可通过NgR siRNA敲除和抑制Rho相关激酶来逆转。坐骨神经压迫后第十四天，与缺乏轴突和髓磷脂的切割/结扎神经相比，用新合成的髓鞘再生的神经巨噬细胞更少。切开/结扎的神经中几乎所有的巨噬细胞都位于雪旺细胞基底层内，而在破碎的再生神经中，大多数移出。此外，NgR1和MAG缺陷小鼠和Y-27632治疗的大鼠的挤压神经损伤后，来自含有髓鞘轴突的Schwann细胞基底层的巨噬细胞外排受损。这些数据对周围神经和中枢神经系统病理炎症的解决具有影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号