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首页> 外文期刊>Neuron >PKA dynamics in a Drosophila learning center: coincidence detection by rutabaga adenylyl cyclase and spatial regulation by dunce phosphodiesterase.
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PKA dynamics in a Drosophila learning center: coincidence detection by rutabaga adenylyl cyclase and spatial regulation by dunce phosphodiesterase.

机译：果蝇学习中心的PKA动态：通过大头菜腺苷酸环化酶的巧合检测和通过磷酸二酯酶的空间调控。

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The dynamics of PKA activity in the olfactory learning and memory center, the mushroom bodies (MBs), are still poorly understood. We addressed this issue in vivo using a PKA FRET probe. Application of dopamine, the main neuromodulator involved in aversive learning, resulted in PKA activation specifically in the vertical lobe, whereas octopamine, involved in appetitive learning, stimulated PKA in all MB lobes. Strikingly, MB lobes were homogeneously activated by dopamine in the learning mutant dunce, showing that Dunce phosphodiesterase plays a major role in the spatial regulation of cAMP dynamics. Furthermore, costimulation with acetylcholine and either dopamine or octopamine led to a synergistic activation of PKA in the MBs that depends on Rutabaga adenylyl cyclase. Our results suggest that Rutabaga acts as a coincidence detector and demonstrate the existence of subcellular domains of PKA activity that could underlie the functional specialization of MB lobes in aversive and appetitive learning.
机译：嗅觉学习和记忆中心，蘑菇体（MBs）中的PKA活动的动力学仍然知之甚少。我们使用PKA FRET探针在体内解决了这个问题。多巴胺（一种参与厌恶性学习的主要神经调节剂）的应用导致PKA在特定的垂直叶特别是激活，而参与开胃性学习的章鱼胺则刺激了所有MB裂片中的PKA。令人惊讶的是，MB瓣在学习突变体dunce中被多巴胺均匀激活，表明Dunce磷酸二酯酶在cAMP动力学的空间调节中起主要作用。此外，与乙酰胆碱和多巴胺或章鱼胺共刺激导致MBs中PKA的协同活化，这取决于大头菜腺苷酸环化酶。我们的结果表明，大头菜可作为巧合检测器，并证明了PKA活性亚细胞域的存在可能是在厌恶性和开胃性学习中MB叶的功能专一化的基础。

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