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首页> 外文期刊>Neuron >Small G protein signaling in neuronal plasticity and memory formation: the specific role of ras family proteins.
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Small G protein signaling in neuronal plasticity and memory formation: the specific role of ras family proteins.

机译：小G蛋白信号传导在神经元可塑性和记忆形成中的作用：ras家族蛋白的特殊作用。

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摘要

Small G proteins are an extensive family of proteins that bind and hydrolyze GTP. They are ubiquitous inside cells, regulating a wide range of cellular processes. Recently, many studies have examined the role of small G proteins, particularly the Ras family of G proteins, in memory formation. Once thought to be primarily involved in the transduction of a variety of extracellular signals during development, it is now clear that Ras family proteins also play critical roles in molecular processing underlying neuronal and behavioral plasticity. We here review a number of recent studies that explore how the signaling of Ras family proteins contributes to memory formation. Understanding these signaling processes is of fundamental importance both from a basic scientific perspective, with the goal of providing mechanistic insights into a critical aspect of cognitive behavior, and from a clinical perspective, with the goal of providing effective therapies for a range of disorders involving cognitive impairments.
机译：小G蛋白是结合并水解GTP的广泛蛋白家族。它们在细胞内部无处不在，调节着广泛的细胞过程。最近，许多研究检查了小G蛋白，特别是Ras G蛋白家族在记忆形成中的作用。一旦被认为主要参与发育过程中各种细胞外信号的转导，现在很清楚，Ras家族蛋白在潜在的神经元和行为可塑性的分子加工中也起着关键作用。我们在这里回顾了许多最近的研究，这些研究探讨了Ras家族蛋白的信号传导如何促进记忆形成。从基本的科学观点出发，以提供对认知行为的关键方面的机械见解的目的，以及从临床的角度出发，以针对涉及认知的一系列疾病提供有效的治疗方法，了解这些信号传导过程至关重要。损害。

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