...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Broad inhibition sharpens orientation selectivity by expanding input dynamic range in mouse simple cells.
【24h】

Broad inhibition sharpens orientation selectivity by expanding input dynamic range in mouse simple cells.

机译：广泛的抑制作用通过扩大小鼠简单细胞中的输入动态范围来增强方向选择性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Orientation selectivity (OS) is an emergent property in the primary visual cortex (V1). How OS arises from synaptic circuits remains unsolved. Here, in vivo whole-cell recordings in the mouse V1 revealed that simple cells received broadly tuned excitation and even more broadly tuned inhibition. Excitation and inhibition shared a similar orientation preference and temporally overlapped substantially. Neuron modeling and dynamic-clamp recording further revealed that excitatory inputs alone would result in membrane potential responses with significantly attenuated selectivity, due to a saturating input-output function of the membrane filtering. Inhibition ameliorated the attenuation of excitatory selectivity by expanding the input dynamic range and caused additional sharpening of output responses beyond unselectively suppressing responses at all orientations. This "blur-sharpening" effect allows selectivity conveyed by excitatory inputs to be better expressed, which may be a general mechanism underlying the generation of feature-selective responses in the face of strong excitatory inputs that are weakly biased.
机译：方向选择性（OS）是主要视觉皮层（V1）中的一种新兴属性。 OS如何从突触电路中产生仍未解决。在这里，小鼠V1体内的全细胞记录表明，简单细胞受到广泛调节的激发，甚至受到广泛调节的抑制。激发和抑制具有相似的取向偏好，并且在时间上基本上重叠。神经元模型和动态钳位记录进一步显示，由于膜过滤的饱和输入-输出功能，单独的兴奋性输入将导致膜电位响应，选择性大大降低。抑制作用通过扩大输入动态范围改善了兴奋性选择性的衰减，并导致输出响应的额外锐化超出了在所有方向上的非选择性抑制响应。这种“模糊锐化”效果可以更好地表达由兴奋性输入传达的选择性，这可能是面对弱偏置的强大兴奋性输入时生成特征选择响应的一般机制。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号