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首页> 外文期刊>Neuron >Decoupling of Sleep-Dependent Cortical and Hippocampal Interactions in a Neurodevelopmental Model of Schizophrenia
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Decoupling of Sleep-Dependent Cortical and Hippocampal Interactions in a Neurodevelopmental Model of Schizophrenia

机译：精神分裂症的神经发育模型中的依赖睡眠的皮质和海马相互作用的解耦。

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Rhythmic neural network activity patterns are defining features of sleep, but interdependencies between limbic and cortical oscillations at different frequencies and their functional roles have not been fully resolved. This is particularly important given evidence linking abnormal sleep architecture and memory consolidation in psychiatric diseases. Using EEG, local field potential (LFP), and unit recordings in rats, we show that anteroposterior propagation of neocortical slow-waves coordinates timing of hippocampal ripples and prefrontal cortical spindles during NREM sleep. This coordination is selectively disrupted in a rat neurodevelopmental model of schizophrenia: fragmented NREM sleep and impaired slow-wave propagation in the model culminate in deficient ripple-spindle coordination and disrupted spike timing, potentially as a consequence of interneuronal abnormalities reflected by reduced parvalbumin expression. These data further define the interrelationships among slow-wave, spindle, and ripple events, indicating that sleep disturbances may be associated with state-dependent decoupling of hippocampal and cortical circuits in psychiatric diseases. A restless pillow makes a ruffled mind? Investigating sleep architecture and associated neural network activity in an animal model of schizophrenia, Phillips et al. propose a new sleep-dependent mechanism for cognitive deficits in neuropsychiatric disease.
机译：节律性神经网络活动模式正在定义睡眠的特征，但是边缘和皮质振荡在不同频率下的相互依赖性及其功能作用尚未得到完全解决。考虑到证据表明精神疾病中异常的睡眠结构和记忆力增强有关，这一点尤其重要。使用脑电图，局域电势（LFP）和大鼠的单位记录，我们显示新皮质慢波的前后传播协调NREM睡眠期间海马波纹和前额叶皮层纺锤体的时间。在精神分裂症的大鼠神经发育模型中有选择地破坏了这种协调性：破碎的NREM睡眠和受损的慢波传播在模型中最终导致纹波主轴协调性不足和尖峰时间受阻，这可能是由于小白蛋白表达减少所反映的神经元间异常的结果。这些数据进一步定义了慢波，纺锤体和波纹事件之间的相互关系，表明睡眠障碍可能与精神疾病中海马和皮层回路的状态依赖性解耦有关。一个不安定的枕头会让心烦意乱吗？ Phillips等在精神分裂症动物模型中研究睡眠结构和相关的神经网络活动。提出了一种新的依赖于神经精神疾病的认知缺陷的依赖睡眠的机制。

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