NMDA Receptor Regulation Prevents Regression of Visual Cortical Function in the Absence of Mecp2

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NMDA Receptor Regulation Prevents Regression of Visual Cortical Function in the Absence of Mecp2

机译：NMDA受体调节可防止Mecp2缺失时视觉皮质功能的退化

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Brain function is shaped by postnatal experience and vulnerable to disruption of Methyl-CpG-binding protein, Mecp2, in multiple neurodevelopmental disorders. How Mecp2 contributes to the experience-dependent refinement of specific cortical circuits and their impairment remains unknown. We analyzed vision in gene-targeted mice and observed an initial normal development in the absence of Mecp2. Visual acuity then rapidly regressed after postnatal day P35-40 and cortical circuits largely fell silent by P55-60. Enhanced inhibitory gating and an excess of parvalbumin-positive, perisomatic input preceded the loss of vision. Both cortical function and inhibitory hyperconnectivity were strikingly rescued independent of Mecp2 by early sensory deprivation or genetic deletion of the excitatory NMDA receptor subunit, NR2A. Thus, vision is a sensitive biomarker of progressive cortical dysfunction and may guide novel, circuit-based therapies for Mecp2 deficiency. Durand et al. demonstrate that hyperconnectivity of a selective inhibitory circuit precedes regression of visual function in mouse models of Rett Syndrome. Cortical dysfunction is rescued by environmental and genetic manipulation and may guide circuit-based therapies for Mecp2 deficiency.

机译：脑部功能受出生后经验的影响，在多种神经发育障碍中易受甲基-CpG结合蛋白Mecp2破坏的影响。 Mecp2如何有助于依赖经验的特定皮层回路的细化及其损伤尚不清楚。我们分析了基因靶向小鼠的视力，并在没有Mecp2的情况下观察到了初始的正常发育。在产后一天P35-40之后，视敏度迅速下降，而P55-60在很大程度上使大脑皮层沉默。在视力丧失之前，抑制性门控的增强和小白蛋白阳性，过氧化物酶体输入过多。皮层功能和抑制性超连通性都通过早期感觉剥夺或兴奋性NMDA受体亚基NR2A的遗传缺失而独立于Mecp2而得到了抢救。因此，视觉是进行性皮质功能障碍的敏感生物标志物，并可能为Mecp2缺乏症提供新颖的，基于回路的疗法。杜兰德等。证明在雷特综合征的小鼠模型中选择性抑制回路的超连通性先于视觉功能的退化。皮质功能障碍可通过环境和基因操作来挽救，并可指导Mecp2缺乏症的基于回路的治疗。

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《Neuron》 |2012年第6期|共13页
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1. NMDA Receptor Regulation Prevents Regression of Visual Cortical Function in the Absence of Mecp2 [J] . Neuron . 2012,第6期

机译：NMDA受体调节可防止Mecp2缺失时视觉皮质功能的退化
2. The 5-HT(1A) receptor agonist 8-OH-DPAT prevents prefrontocortical glutamate and serotonin release in response to blockade of cortical NMDA receptors. [J] . Calcagno E, Carli M, Invernizzi RW Journal of Neurochemistry: Offical Journal of the International Society for Neurochemistry . 2006,第3期

机译：5-HT（1A）受体激动剂8-OH-DPAT可阻止皮质NMDA受体的响应而释放前额叶谷氨酸和5-羟色胺。
3. ICAM-5 affects spine maturation by regulation of NMDA receptor binding to ???±-actinin ICAM-5 affects spine maturation by regulation of NMDA receptor binding to ???±-actinin ICAM-5 affects spine maturation by regulation of NMDA receptor binding to ???±-actinin [J] . Carl G. Gahmberg, Lin Ning, Henrietta Nyman-Huttunen, Biology Open . 2015,第2期

机译：ICAM-5通过调节NMDA受体与±-肌动蛋白的结合来影响脊柱成熟ICAM-5通过调节NMDA受体与±-肌动蛋白的结合来影响脊柱成熟ICAM-5通过调节NMDA受体结合来影响脊柱成熟。到±肌动蛋白
4. EFFECTS OF NMDA AND NON-NMDA RECEPTORS ANTAGONISTS ON THE BEHAVIOR OF CULTURED CORTICAL NETWORKS [C] . Laura Bonzano, Marco Bove, Sergio Martinoia Brain Inspired Cognitive Systems . 2004

机译：NMDA和非NMDA受体对拮抗剂对培养皮质网络行为的影响
5. Experience-dependent regulation of presynaptic NMDA receptors (preNMDARs) and their role in neurotransmission and synaptic plasticity. [D] . Corlew, Rebekah. 2009

机译：经验依赖的突触前NMDA受体（preNMDARs）的调节及其在神经传递和突触可塑性中的作用。
6. NMDA Receptor Regulation Prevents Regression of Visual Cortical Function in the Absence of Mecp2 [O] . Severine Durand, Annarita Patrizi, Kathleen B. Quast, -1

机译：视觉皮质功能的NmDa受体调节功能可防止回归中的mecp2缺位
7. NMDA Receptor Regulation Prevents Regression of Visual Cortical Function in the Absence of Mecp2 [O] . Durand Severine, Patrizi Annarita, Quast Kathleen B., 2012

机译：NMDA受体调节可防止Mecp2缺失时视觉皮质功能的退化

NMDA Receptor Regulation Prevents Regression of Visual Cortical Function in the Absence of Mecp2

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