Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria

Kabouridis Panagiotis S.; Lasrado Reena; McCallum Sarah; Chng Song Hui; Snippert Hugo J.; Clevers Hans; Pettersson Sven; Pachnis Vassilis

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Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria

机译：微生物群控制肠道固有层中胶质细胞的稳态

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The intrinsic neural networks of the gastrointestinal tract are derived from dedicated neural crest progenitors that colonize the gut during embryogenesis and give rise to enteric neurons and glia. Here, we study how an essential subpopulation of enteric glial cells (EGCs) residing within the intestinal mucosa is integrated into the dynamic microenvironment of the alimentary tract. We find that under normal conditions colonization of the lamina propria by glial cells commences during early postnatal stages but reaches steady-state levels after weaning. By employing genetic lineage tracing, we provide evidence that in adult mice the network of mucosal EGCs is continuously renewed by incoming glial cells originating in the plexi of the gut wall. Finally, we demonstrate that both the initial colonization and homeostasis of glial cells in the intestinal mucosa are regulated by the indigenous gut microbiota.

机译：胃肠道的内在神经网络源自专用的神经rest祖细胞，这些祖细胞在胚胎发生过程中定居于肠道，并产生肠神经元和神经胶质。在这里，我们研究了肠道粘膜内肠神经胶质细胞（EGCs）的基本亚群如何整合到消化道的动态微环境中。我们发现，在正常情况下，由胶质细胞在固有层中定植是在产后早期开始的，但在断奶后达到稳态水平。通过采用遗传谱系追踪，我们提供了证据，在成年小鼠中，粘膜EGC的网络被源自肠壁丛的传入神经胶质细胞不断更新。最后，我们证明肠道黏膜中神经胶质细胞的最初定植和体内平衡都受到本地肠道菌群的调节。

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《Neuron》 |2015年第2期|共7页
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Kabouridis Panagiotis S.; Lasrado Reena; McCallum Sarah; Chng Song Hui; Snippert Hugo J.; Clevers Hans; Pettersson Sven; Pachnis Vassilis;
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中图分类神经病学;
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1. Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria [J] . Kabouridis Panagiotis S., Lasrado Reena, McCallum Sarah, Neuron . 2015,第Pta2期

机译：微生物群控制肠道固有层中胶质细胞的稳态
2. MR1-Restricted V{alpha}19i Mucosal-Associated Invariant T Cells Are Innate T Cells in the Gut Lamina Propria That Provide a Rapid and Diverse Cytokine Response. [J] . Kawachi I, Maldonado J, Strader C, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2006,第3期

机译：MR1限制性V {alpha} 19i粘膜相关的不变T细胞是固有肠T细胞中固有的T细胞，提供快速而多样的细胞因子反应。
3. MR1-Restricted Vα19i Mucosal-Associated Invariant T Cells Are Innate T Cells in the Gut Lamina Propria That Provide a Rapid and Diverse Cytokine Response [J] . Izumi Kawachi, Jorge Maldonado, Carey Strader, The journal of immunology . 2006,第3期

机译：MR1限制的Vα19i粘膜相关的不变T细胞是固有肠T细胞中固有的T细胞，可提供快速而多样的细胞因子反应。
4. MECHANICAL PROPERTIES OF THE FETAL BOVINE BLADDER LAMINA PROPRIA AND THEIR CORRELATION WITH CHANGES IN EXTRACELLULAR MATRIX [C] . Robert S. Cargill II, Kevin K. Toosi, Edward J. Macarak ASME summer bioengineering conference;SBC2008 . 2009

机译：胎牛膀胱固有层的力学性能及其与细胞外基质变化的相关性
5. The Short Chain Fatty Acid Receptor, Free Fatty Acid-2 Receptor (FFA2), Contributes to Gestational Glucose Homeostasis through a Novel Relationship Between Pancreatic Beta Cells, Short Chain Fatty Acids and the Gut Microbiota. [D] . Fuller, Miles Henry. 2016

机译：短链脂肪酸受体，游离脂肪酸2受体（FFA2）通过胰腺β细胞，短链脂肪酸和肠道菌群之间的新关系，有助于妊娠期葡萄糖体内稳态。
6. Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria [O] . Panagiotis S. Kabouridis, Reena Lasrado, Sarah McCallum, -1

机译：微生物群控制肠道固有层中胶质细胞的稳态
7. Microbiota controls the homeostasis of glial cells in the gut lamina propria [O] . Kabouridis, Panagiotis S, Lasrado, Reena, McCallum, Sarah, 2015

机译：微生物群控制肠道固有层中神经胶质细胞的稳态
8. Repopulation of the Gut Lamina Propria with IgA Containing Cells by Lymphoid Cells Isolated from the Gut Lamina Propria (Homing of Gut IgA Cells) [R] . Tseng, J. 1984

机译：通过从肠道固有层分离的淋巴细胞（肠道Iga细胞的归巢）重建含有Iga的肠道的肠道固有层

Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria

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