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首页> 外文期刊>Neuron >Experience-Dependent Bimodal Plasticity of Inhibitory Neurons in Early Development
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Experience-Dependent Bimodal Plasticity of Inhibitory Neurons in Early Development

机译：抑制神经元在早期发育中的经验依赖性双峰可塑性。

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Inhibitory neurons are heterogeneous in the mature brain. It is unclear when and how inhibitory neurons express distinct structural and functional profiles. Using in vivo time-lapse imaging of tectal neuron structure and visually evoked Ca2+ responses in tadpoles, we found that inhibitory neurons cluster into two groups with opposite valence of plasticity after 4 hr of dark and visual stimulation. Half decreased dendritic arbor size and Ca2+ responses after dark and increased them after visual stimulation, matching plasticity in excitatory neurons. Half increased dendrite arbor size and Ca2+ responses following dark and decreased them after stimulation. At the circuit level, visually evoked excitatory and inhibitory synaptic inputs were potentiated by visual experience and E/I remained constant. Our results indicate that developing inhibitory neurons fall into distinct functional groups with opposite experience-dependent plasticity and as such, are well positioned to foster experience-dependent synaptic plasticity and maintain circuit stability during labile periods of circuit development.
机译：抑制性神经元在成熟的大脑中是异质的。尚不清楚何时以及如何抑制神经元表达不同的结构和功能配置文件。使用体内延时成像的神经元结构和visual诱发的Ca2 +应答，我们发现在黑暗和视觉刺激4小时后，抑制性神经元聚集成两组，其可塑性相反。一半在黑暗后降低树突状乔木大小和Ca2 +响应，并在视觉刺激后增加它们，与兴奋性神经元的可塑性匹配。黑暗后一半增加树枝状乔木大小和Ca2 +响应，刺激后降低一半。在电路水平上，视觉体验增强了视觉诱发的兴奋性和抑制性突触输入，并且E / I保持恒定。我们的结果表明，发展中的抑制神经元可分为不同的功能组，它们具有相反的经验依赖性可塑性，因此，在电路发展的不稳定时期，可以很好地促进经验依赖性突触可塑性并保持电路稳定性。

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