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首页> 外文期刊>Neuron >Convergent inductive signals specify midbrain, hindbrain, and spinal cord identity in gastrula stage chick embryos.
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Convergent inductive signals specify midbrain, hindbrain, and spinal cord identity in gastrula stage chick embryos.

机译：会聚的感应信号指定了下腹阶段雏鸡胚胎的中脑，后脑和脊髓特性。

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摘要

In the chick embryo, neural cells acquire midbrain, hindbrain, and spinal cord character over a approximately 6 hr period during gastrulation. The convergent actions of four signals appear to specify caudal neural character. Fibroblast growth factors (FGFs) and a paraxial mesoderm-caudalizing (PMC) activity are involved, but neither signal is sufficient to induce any single region. FGFs act indirectly by inducing mesoderm that expresses PMC and retinoid activity and also directly on prospective neural cells, in combination with PMC activity and a rostralizing signal, to induce midbrain character. Hindbrain character emerges from cells that possess the potential to acquire midbrain character upon exposure to higher levels of PMC activity. Induction of spinal cord character appears to involve PMC and retinoid activities.
机译：在雏鸡的胚胎中，大约在6小时内，神经细胞在中胚层中获得中脑，后脑和脊髓的特征。四个信号的收敛作用似乎表明了尾神经特性。涉及成纤维细胞生长因子（FGFs）和近轴中胚层尾部化（PMC）活性，但两种信号均不足以诱导任何单个区域。 FGFs通过诱导表达PMC和类维生素A活性的中胚层间接作用，并直接在前瞻性神经细胞上与PMC活性和有鼻刺激性信号结合，诱导中脑特征。后脑特征从具有更高水平PMC活性的潜在获得中脑特征的细胞中显现出来。脊髓特征的诱导似乎涉及PMC和类维生素A活性。

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