...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptors at synapses in hippocampal cultures and slices (see comments)
【24h】

Variability of neurotransmitter concentration and nonsaturation of postsynaptic AMPA receptors at synapses in hippocampal cultures and slices (see comments)

机译：海马培养物和切片中突触后神经递质浓度的变化和突触后AMPA受体的不饱和性（参见评论）

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To understand the elementary unit of synaptic communication between CNS neurons, one must know what causes the variability of quantal postsynaptic currents and whether unitary packets of transmitter saturate postsynaptic receptors. We studied single excitatory synapses between hippocampal neurons in culture. Focal glutamate application at individual postsynaptic sites evoked currents (I(glu)) with little variability compared with quantal excitatory postsynaptic currents (EPSCs). The maximal I(glu) was >2-fold larger than the median EPSC. Thus, variations in [glu]cleft are the main source of variability in EPSC size, and glutamate receptors are generally far from saturation during quantal transmission. This conclusion was verified by molecular antagonism experiments in hippocampal cultures and slices. The general lack of glutamate receptor saturation leaves room for increases in [glu]cleft as a mechanism for synaptic plasticity.
机译：要了解中枢神经系统神经元之间突触通讯的基本单位，必须知道是什么引起了定量突触后电流的变化，以及发射器的单个信息包是否饱和了突触后受体。我们研究了文化中海马神经元之间的单个兴奋性突触。与定量兴奋性突触后突触电流（EPSCs）相比，在各个突触后突触部位局部应用谷氨酸盐可以诱发电流（I（glu））。最大I（glu）比中位数EPSC大2倍以上。因此，glu裂的变化是EPSC大小变化的主要来源，并且谷氨酸受体在定量传递过程中通常远离饱和。该结论通过海马培养物和切片中的分子拮抗实验得到了证实。谷氨酸受体饱和度的普遍缺乏留出了作为裂口可塑性机制的黄裂增加的空间。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号