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首页> 外文期刊>Neuron >Temporal control of glial cell migration in the Drosophila eye requires gilgamesh, hedgehog, and eye specification genes.
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Temporal control of glial cell migration in the Drosophila eye requires gilgamesh, hedgehog, and eye specification genes.

机译:果蝇眼中神经胶质细胞迁移的时间控制需要吉尔伽美什,刺猬和眼睛特定基因。

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摘要

In the Drosophila visual system, photoreceptor neurons (R cells) extend axons towards glial cells located at the posterior edge of the eye disc. In gilgamesh (gish) mutants, glial cells invade anterior regions of the eye disc prior to R cell differentiation and R cell axons extend anteriorly along these cells. gish encodes casein kinase Igamma. gish, sine oculis, eyeless, and hedgehog (hh) act in the posterior region of the eye disc to prevent precocious glial cell migration. Targeted expression of Hh in this region rescues the gish phenotype, though the glial cells do not require the canonical Hh signaling pathway to respond. We propose that the spatiotemporal control of glial cell migration plays a critical role in determining the directionality of R cell axon outgrowth.
机译:在果蝇视觉系统中,感光神经元(R细胞)将轴突向位于眼球后缘的神经胶质细胞延伸。在吉尔伽美什(gish)突变体中,神经胶质细胞在R细胞分化之前侵入眼球的前部区域,R细胞轴突沿这些细胞向前延伸。 gish编码酪蛋白激酶Igamma。腮腺,正弦眼,无眼和刺猬(hh)作用于眼球后部,以防止早熟的胶质细胞迁移。尽管神经胶质细胞不需要规范的Hh信号通路来响应,但Hh在该区域的靶向表达可以挽救表型。我们建议时空控制的胶质细胞迁移在决定R细胞轴突向外生长的方向性中起着至关重要的作用。

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