Fear Memory Formation Involves p190 RhoGAP and ROCK Proteins through a GRB2-Mediated Complex.

Lamprecht R; Farb CR; LeDoux JE

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Fear Memory Formation Involves p190 RhoGAP and ROCK Proteins through a GRB2-Mediated Complex.

机译：恐惧记忆形成通过GRB2介导的复合体涉及p190 RhoGAP和ROCK蛋白。

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We used fear conditioning, which is known to alter synaptic efficacy in lateral amygdala (LA), to study molecular mechanisms underlying long-term memory. Following fear conditioning, the tyrosine phosphorylated protein p190 RhoGAP becomes associated with GRB2 in LA significantly more in conditioned than in control rats. RasGAP and Shc were also found to associate with GRB2 in LA significantly more in the conditioned animals. Inhibition of the p190 RhoGAP-downstream kinase ROCK in LA during fear conditioning impaired long- but not short-term memory. Thus, the p190 RhoGAP/ROCK pathway, which regulates the morphology of dendrites and axons during neural development, plays a central role, through a GRB2-mediated molecular complex, in fear memory formation in the lateral amygdala.

机译：我们使用恐惧调节来研究长期记忆的分子机制，恐惧调节可以改变外侧杏仁核（LA）的突触功效。在恐惧条件下，酪氨酸磷酸化蛋白p190 RhoGAP在条件条件下的LA中与GRB2的关系要明显多于对照大鼠。在条件动物中，还发现RasGAP和Shc与LA中GRB2的关联明显更多。在恐惧调节期间，LA中p190 RhoGAP下游激酶ROCK的抑制会损害长期记忆，而不是短期记忆。因此，在神经发育过程中调节树突和轴突的形态的p190 RhoGAP / ROCK途径，通过GRB2介导的分子复合物，在外侧杏仁核的恐惧记忆形成中起着核心作用。

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《Neuron》 |2002年第4期|共12页
作者
Lamprecht R; Farb CR; LeDoux JE;
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正文语种 eng
中图分类神经生理学;
关键词
Fright; Lanthanum; Proteins; Conditioning (Psychology); Memory observations; 镧; 蛋白质类; 条件反射(心理学);

机译：Fright;Lanthanum;Proteins;Conditioning (Psychology);Memory observations;镧;蛋白质类;条件反射(心理学);

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1. Fear Memory Formation Involves p190 RhoGAP and ROCK Proteins through a GRB2-Mediated Complex. [J] . Lamprecht R, Farb CR, LeDoux JE Neuron . 2002,第4期

机译：恐惧记忆形成通过GRB2介导的复合体涉及p190 RhoGAP和ROCK蛋白。
2. Phosphotyrosine (p-Tyr)-Dependent and -Independent Mechanisms of p190 RhoGAP-p120 RasGAP Interaction: Tyr 1105 of p190, a Substrate for c-Src, Is the Sole p-Tyr Mediator of Complex Formation [J] . Richard W. Roof, Michelle D. Haskell, Bernard D. Dukes, Molecular and Cellular Biology . 1998,第12期

机译：p190 RhoGAP-p120 RasGAP相互作用的磷酸酪氨酸（p-Tyr）依赖性和非依赖性机制：p190的Tyr 1105（c-Src的底物）是复合物形成的唯一p-Tyr介体
3. Rnd proteins function as RhoA antagonists by activating p190 RhoGAP [J] . Wennerberg K., Forget MA., Ellerbroek SM., Current Biology: CB . 2003,第13期

机译：Rnd蛋白通过激活p190 RhoGAP充当RhoA拮抗剂
4. A Constitutive Model for Shape Memory Alloys Involving Transformation, Reorientation and Plasticity [C] . Xianghe Peng, Minmei Chen, Jun Wang Asia_Pacific Conference on Engineering Plasticity and its Applications . 2013

机译：涉及转化，重新定向和可塑性形状记忆合金的本构模型
5. Acutely increasing alpha calcium/calmodulin-dependent protein kinase II in lateral amygdala enhances auditory fear conditioning memory. [D] . Hsiang, Hwa-Lin. 2008

机译：在外侧杏仁核中急性增加的α钙/钙调蛋白依赖性蛋白激酶II增强听觉恐惧条件记忆。
6. Phosphotyrosine (p-Tyr)-Dependent and -Independent Mechanisms of p190 RhoGAP-p120 RasGAP Interaction: Tyr 1105 of p190 a Substrate for c-Src Is the Sole p-Tyr Mediator of Complex Formation [O] . Richard W. Roof, Michelle D. Haskell, Bernard D. Dukes, 1998

机译：p190 RhoGAP-p120 RasGAP相互作用的磷酸酪氨酸（p-Tyr）依赖性和非依赖性机制：p190的Tyr 1105c-Src的底物是复杂形成的唯一p-Tyr介体
7. Fear Memory Formation Involves p190 RhoGAP and ROCK Proteins through a GRB2-Mediated Complex [O] . Lamprecht Raphael, Farb Claudia R, LeDoux Joseph E 2002

机译：恐惧记忆形成通过GRB2介导的复合体涉及p190 RhoGAP和ROCK蛋白。

Fear Memory Formation Involves p190 RhoGAP and ROCK Proteins through a GRB2-Mediated Complex.

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