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首页> 外文期刊>Neuron >The translational repressor Pumilio regulates presynaptic morphology and controls postsynaptic accumulation of translation factor eIF-4E.
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The translational repressor Pumilio regulates presynaptic morphology and controls postsynaptic accumulation of translation factor eIF-4E.

机译：翻译阻遏物Pumilio调节突触前形态并控制突触后eIF-4E的积累。

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摘要

Translational repression by Drosophila Pumilio (Pum) protein controls posterior patterning during embryonic development. Here, we show that Pum is an important mediator of synaptic growth and plasticity at the neuromuscular junction (NMJ). Pum is localized to the postsynaptic side of the NMJ in third instar larvae and is also expressed in larval neurons. Neuronal Pum regulates synaptic growth. In its absence, NMJ boutons are larger and fewer in number, while Pum overexpression increases bouton number and decreases bouton size. Postsynaptic Pum negatively regulates expression of the translation factor eIF-4E at the NMJ, and Pum binds selectively to the 3'UTR of eIF-4E mRNA. The GluRIIa glutamate receptor is upregulated in pum mutants. These results, together with genetic epistasis studies, suggest that postsynaptic Pum modulates synaptic function via direct control of eIF-4E expression.
机译：果蝇Pumlio（Pum）蛋白的翻译抑制可控制胚胎发育过程中的后部模式。在这里，我们显示Pum是神经肌肉接头（NMJ）突触生长和可塑性的重要介体。 Pum位于三龄幼虫的NMJ突触后侧，并在幼虫神经元中表达。神经元Pum调节突触生长。在缺少它的情况下，NMJ布顿数更大且数量更少，而Pum过表达会增加布顿数并减小布顿大小。突触后Pum在NMJ负调节翻译因子eIF-4E的表达，并且Pum选择性结合eIF-4E mRNA的3'UTR。在pum突变体中，GluRIIa谷氨酸受体被上调。这些结果以及遗传上位研究表明，突触后的Pum通过直接控制eIF-4E表达来调节突触功能。

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