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首页> 外文期刊>Neuron >Presynaptic and postsynaptic roles of NO, cGK, and RhoA in long-lasting potentiation and aggregation of synaptic proteins.
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Presynaptic and postsynaptic roles of NO, cGK, and RhoA in long-lasting potentiation and aggregation of synaptic proteins.

机译：NO，cGK和RhoA在突触蛋白的持久增强和聚集中的突触前和突触后作用。

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Recent results suggest that long-lasting potentiation at hippocampal synapses involves the rapid formation of clusters or puncta of presynaptic as well as postsynaptic proteins, both of which are blocked by antagonists of NMDA receptors and an inhibitor of actin polymerization. We have investigated whether the increase in puncta involves retrograde signaling through the NO-cGMP-cGK pathway and also examined the possible roles of two classes of molecules that regulate the actin cytoskeleton: Ena/VASP proteins and Rho GTPases. Our results suggest that NO, cGMP, cGK, actin, and Rho GTPases including RhoA play important roles in the potentiation and act directly in both the presynaptic and postsynaptic neurons, where they contribute to the increase in puncta of synaptic proteins. cGK phosphorylates synaptic VASP during the potentiation, whereas Rho GTPases act both in parallel and upstream of cGMP, in part by maintaining the synaptic localization of soluble guanylyl cyclase.
机译：最近的结果表明，海马突触的长时程增强涉及突触前和突触后蛋白的簇或突点的快速形成，两者均被NMDA受体拮抗剂和肌动蛋白聚合抑制剂所阻断。我们研究了泪点的增加是否涉及通过NO-cGMP-cGK途径进行的逆行信号传导，并且还研究了调节肌动蛋白细胞骨架的两类分子的可能作用：Ena / VASP蛋白和Rho GTPases。我们的结果表明，NO，cGMP，cGK，肌动蛋白和Rho GTP酶（包括RhoA）在增强作用中起着重要作用，并直接作用于突触前和突触后神经元，在神经元中它们会增加突触蛋白的点数。 cGK在增强过程中使突触VASP磷酸化，而Rho GTPases在cGMP的平行和上游均起作用，部分是通过维持可溶性鸟苷酸环化酶的突触定位来实现的。

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