...
首页> 外文期刊>Neuron >Genetic mechanisms specifying cortical connectivity: let's make some projections together.
【24h】

Genetic mechanisms specifying cortical connectivity: let's make some projections together.

机译:指定皮质连通性的遗传机制:让我们一起做出一些预测。

获取原文
获取原文并翻译 | 示例
           

摘要

Great neuroanatomists of the twentieth century recognized that the cerebral cortex of mammals is the single most complex structure of the central nervous system both in terms of neuronal diversity and connectivity. Understanding the cellular and molecular mechanisms specifying the afferent and efferent connectivity in the neocortex may seem like a daunting task. However, recent technical advances have greatly improved our ability to (1) profile gene expression of neuronal populations isolated based on their connectional properties, (2) manipulate gene expression in specific neuronal populations, and (3) visualize their axonal projections in vivo. These new tools are revolutionizing our ability to identify the molecular mechanisms patterning afferent and efferent cortical projections.
机译:二十世纪的伟大神经解剖学家认识到,就神经元多样性和连通性而言,哺乳动物的大脑皮层是中枢神经系统中最复杂的单个结构。了解指定新皮层中传入和传出连接的细胞和分子机制似乎是一项艰巨的任务。但是,最近的技术进步极大地提高了我们的能力:(1)基于它们的连接特性来分析分离的神经元群体的基因表达;(2)操纵特定神经元群体中的基因表达;(3)可视化它们在体内的轴突投影。这些新工具正在彻底改变我们识别模式化传入和传出皮质投影的分子机制的能力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号