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首页> 外文期刊>Neuron >Synaptic mechanisms of associative memory in the amygdala.
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Synaptic mechanisms of associative memory in the amygdala.

机译:杏仁核中联想记忆的突触机制。

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摘要

Do associative learning and synaptic long-term potentiation (LTP) depend on the same cellular mechanisms? Recent work in the amygdala reveals that LTP and Pavlovian fear conditioning induce similar changes in postsynaptic AMPA-type glutamate receptors and that occluding these changes by viral-mediated overexpression of a dominant-negative GluR1 construct attenuates both LTP and fear memory in rats. Novel forms of presynaptic plasticity in the lateral nucleus may also contribute to fear memory formation, bolstering the connection between synaptic plasticity mechanisms and associative learning and memory.
机译:联想学习和突触长期增强(LTP)是否依赖于相同的细胞机制?杏仁核的最新研究表明LTP和Pavlovian恐惧条件在突触后AMPA型谷氨酸受体中诱导了相似的变化,并且通过病毒介导的显性负性GluR1构建体的过度表达而阻断了这些变化,从而减弱了大鼠的LTP和恐惧记忆。外侧核中新形式的突触前可塑性也可能有助于恐惧记忆的形成,加强突触可塑性机制与联想学习和记忆之间的联系。

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