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首页> 外文期刊>Neuron >Long-term potentiation of neuronal glutamate transporters.
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Long-term potentiation of neuronal glutamate transporters.

机译：神经元谷氨酸转运蛋白的长期增强。

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摘要

Persistent, use-dependent modulation of synaptic strength has been demonstrated for fast synaptic transmission mediated by glutamate and has been hypothesized to underlie persistent behavioral changes ranging from memory to addiction. Glutamate released at synapses is sequestered by the action of excitatory amino acid transporters (EAATs) in glia and postsynaptic neurons. So, the efficacy of glutamate transporter function is crucial for regulating glutamate spillover to adjacent presynaptic and postsynaptic receptors and the consequent induction of plastic or excitotoxic processes. Here, we report that tetanic stimulation of cerebellar climbing fiber-Purkinje cell synapses results in long-term potentiation (LTP) of a climbing fiber-evoked glutamate transporter current recorded in Purkinje cells. This LTP is postsynaptically expressed and requires activation of an mGluR1/PKC cascade. Together with a simultaneously induced long-term depression (LTD) of postsynaptic AMPA receptors, this might reflect an integrated antiexcitotoxic cellular response to strong climbing fiber synaptic activation, as occurs following an ischemic episode.
机译：持久性的，依赖于使用的突触强度调节已被证明可用于由谷氨酸介导的快速突触传递，并被认为是从记忆到成瘾的持续行为改变的基础。突触释放的谷氨酸盐被神经胶质细胞和突触后神经元中的兴奋性氨基酸转运蛋白（EAAT）作用隔离。因此，谷氨酸转运蛋白功能的功效对于调节谷氨酸向邻近突触前和突触后受体的溢出以及随后诱导的塑性或兴奋性毒性过程至关重要。在这里，我们报告强直性刺激小脑攀登纤维-Purkinje细胞突触导致记录在浦肯野细胞中的攀登纤维诱发的谷氨酸转运蛋白电流的长期增强（LTP）。该LTP是突触后表达的，需要激活mGluR1 / PKC级联。与同时诱发突触后AMPA受体的长期抑制（LTD）一起，这可能反映出对缺血性发作后发生的对强力攀爬纤维突触激活的综合抗兴奋性细胞应答。

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