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首页> 外文期刊>Neuron >Axonal speeding: shaping synaptic potentials in small neurons by the axonal membrane compartment.
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Axonal speeding: shaping synaptic potentials in small neurons by the axonal membrane compartment.

机译:轴突超速:通过轴突膜区室在小神经元中塑造突触电位。

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摘要

The role of the axonal membrane compartment in synaptic integration is usually neglected. We show here that in interneurons of the cerebellar molecular layer, where dendrites are so short that the somatodendritic domain can be considered isopotential, the axonal membrane contributes a significant part of the cell input capacitance. We examine the impact of axonal membrane on synaptic integration by cutting the axon with two-photon illumination. We find that the axonal compartment acts as a sink for signals generated at fast conductance synapses, thus increasing the initial decay rate of corresponding synaptic potentials over the value predicted from the resistance-capacitance (RC) product of the cell membrane; signals generated at slower synapses are much less affected. This mechanism sharpens the spike firing precision of fast glutamatergic inputs without resorting to multisynaptic pathways.
机译:通常忽略轴突膜区隔在突触整合中的作用。我们在这里表明,在小脑分子层的中间神经元中,树突非常短,以致于体树突状结构域可以被认为是等电位的,轴突膜贡献了细胞输入电容的很大一部分。我们通过用两光子照明切割轴突来检查轴突膜对突触整合的影响。我们发现,轴突区室充当快速电导突触产生的信号的汇,从而增加了相应突触电位的初始衰减率,其超过了从细胞膜电阻-电容(RC)乘积预测的值。在较慢的突触中产生的信号受到的影响要小得多。该机制提高了快速谷氨酸能输入的尖峰发射精度,而无需诉诸多突触途径。

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