...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Neuron >Rapid bidirectional switching of synaptic NMDA receptors.
【24h】

Rapid bidirectional switching of synaptic NMDA receptors.

机译：突触NMDA受体的快速双向切换。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Synaptic NMDA-type glutamate receptors (NMDARs) play important roles in synaptic plasticity, brain development, and pathology. In the last few years, the view of NMDARs as relatively fixed components of the postsynaptic density has changed. A number of studies have now shown that both the number of receptors and their subunit compositions can be altered. During development, the synaptic NMDARs subunit composition changes, switching from predominance of NR2B-containing to NR2A-containing receptors, but little is known about the mechanisms involved in this developmental process. Here, we report that, depending on the pattern of NMDAR activation, the subunit composition of synaptic NMDARs is under extremely rapid, bidirectional control at neonatal synapses. This switching, which is at least as rapid as that seen with AMPARs, will have immediate and dramatic consequences on the integrative capacity of the synapse.
机译：突触NMDA型谷氨酸受体（NMDAR）在突触可塑性，大脑发育和病理学中起重要作用。在最近几年中，NMDARs作为突触后密度的相对固定成分的观点已经改变。现在的许多研究表明，受体的数量及其亚基组成都可以改变。在发育过程中，突触NMDARs亚基组成发生变化，从含NR2B受体转变为含NR2A受体，但对该发育过程涉及的机制知之甚少。在这里，我们报告，根据NMDAR激活的模式，突触NMDARs的亚基组成在新生儿突触处于非常快速的双向控制下。这种切换至少与AMPAR所见的一样快，将对突触的整合能力产生直接而戏剧性的影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号